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Surface plasmon-enhanced fluorescence on Au nanohole array for prostate-specific antigen detection

Overview of attention for article published in International Journal of Nanomedicine, March 2017
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20 Mendeley
Title
Surface plasmon-enhanced fluorescence on Au nanohole array for prostate-specific antigen detection
Published in
International Journal of Nanomedicine, March 2017
DOI 10.2147/ijn.s128172
Pubmed ID
Authors

Qingwen Zhang, Lin Wu, Ten It Wong, Jinling Zhang, Xiaohu Liu, Xiaodong Zhou, Ping Bai, Bo Liedberg, Yi Wang

Abstract

Localized surface plasmon (LSP) has been widely applied for the enhancement of fluorescence emission for biosensing owing to its potential for strong field enhancement. However, due to its small penetration depth, LSP offers limited fluorescence enhancement over a whole sensor chip and, therefore, insufficient sensitivity for the detection of biomolecules, especially large molecules. We demonstrate the simultaneous excitation of LSP and propagating surface plasmon (PSP) on an Au nanohole array under Kretschmann configuration for the detection of prostate-specific antigen with a sandwich immunoassay. The proposed method combines the advantages of high field enhancement by LSP and large surface area probed by PSP field. The simulated results indicated that a maximum enhancement of electric field intensity up to 1,600 times can be achieved under the simultaneous excitation of LSP and PSP modes. The sandwich assay of PSA carried out on gold nanohole array substrate showed a limit of detection of 140 fM supporting coexcitation of LSP and PSP modes. The limit of detection was approximately sevenfold lower than that when only LSP was resonantly excited on the same substrate. The results of this study demonstrate high fluorescence enhancement through the coexcitation of LSP and PSP modes and pave a way for its implementation as a highly sensitive bioassay.

Twitter Demographics

The data shown below were collected from the profiles of 2 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 20 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 20 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 4 20%
Student > Ph. D. Student 4 20%
Researcher 3 15%
Student > Master 2 10%
Professor 1 5%
Other 4 20%
Unknown 2 10%
Readers by discipline Count As %
Physics and Astronomy 4 20%
Chemistry 4 20%
Biochemistry, Genetics and Molecular Biology 3 15%
Engineering 3 15%
Agricultural and Biological Sciences 2 10%
Other 1 5%
Unknown 3 15%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 11 April 2017.
All research outputs
#8,822,864
of 11,465,443 outputs
Outputs from International Journal of Nanomedicine
#1,653
of 2,275 outputs
Outputs of similar age
#175,663
of 266,423 outputs
Outputs of similar age from International Journal of Nanomedicine
#41
of 81 outputs
Altmetric has tracked 11,465,443 research outputs across all sources so far. This one is in the 19th percentile – i.e., 19% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,275 research outputs from this source. They receive a mean Attention Score of 3.0. This one is in the 21st percentile – i.e., 21% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 266,423 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 27th percentile – i.e., 27% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 81 others from the same source and published within six weeks on either side of this one. This one is in the 37th percentile – i.e., 37% of its contemporaries scored the same or lower than it.