Title |
Antiviral activity of mycosynthesized silver nanoparticles against herpes simplex virus and human parainfluenza virus type 3
|
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Published in |
International Journal of Nanomedicine, November 2013
|
DOI | 10.2147/ijn.s50070 |
Pubmed ID | |
Authors |
Swapnil Gaikwad, Avinash Ingle, Aniket Gade, Mahendra Rai, Annarita Falanga, Novella Incoronato, Luigi Russo, Stefania Galdiero, Massimilano Galdiero |
Abstract |
The interaction between silver nanoparticles and viruses is attracting great interest due to the potential antiviral activity of these particles, and is the subject of much research effort in the treatment of infectious diseases. In this work, we demonstrate that silver nanoparticles undergo a size-dependent interaction with herpes simplex virus types 1 and 2 and with human parainfluenza virus type 3. We show that production of silver nanoparticles from different fungi is feasible, and their antiviral activity is dependent on the production system used. Silver nanoparticles are capable of reducing viral infectivity, probably by blocking interaction of the virus with the cell, which might depend on the size and zeta potential of the silver nanoparticles. Smaller-sized nanoparticles were able to inhibit the infectivity of the viruses analyzed. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 3 | 16% |
Russia | 1 | 5% |
Canada | 1 | 5% |
Turkey | 1 | 5% |
Unknown | 13 | 68% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 16 | 84% |
Practitioners (doctors, other healthcare professionals) | 2 | 11% |
Scientists | 1 | 5% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | <1% |
Poland | 1 | <1% |
Unknown | 310 | 99% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 50 | 16% |
Student > Master | 42 | 13% |
Researcher | 39 | 13% |
Student > Bachelor | 23 | 7% |
Student > Doctoral Student | 12 | 4% |
Other | 42 | 13% |
Unknown | 104 | 33% |
Readers by discipline | Count | As % |
---|---|---|
Chemistry | 34 | 11% |
Agricultural and Biological Sciences | 33 | 11% |
Biochemistry, Genetics and Molecular Biology | 24 | 8% |
Engineering | 20 | 6% |
Materials Science | 15 | 5% |
Other | 65 | 21% |
Unknown | 121 | 39% |