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Improved antibacterial activity and biocompatibility on vancomycin-loaded TiO2 nanotubes: in vivo and in vitro studies

Overview of attention for article published in International Journal of Nanomedicine, November 2013
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About this Attention Score

  • Above-average Attention Score compared to outputs of the same age (51st percentile)

Mentioned by

twitter
3 tweeters

Citations

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66 Dimensions

Readers on

mendeley
61 Mendeley
Title
Improved antibacterial activity and biocompatibility on vancomycin-loaded TiO2 nanotubes: in vivo and in vitro studies
Published in
International Journal of Nanomedicine, November 2013
DOI 10.2147/ijn.s53221
Pubmed ID
Authors

Hangzhou Zhang, Sun Yu, Ang Tian, Wang Lin, Alquhali Ali, Xiangxin Xue, Xi Zhuang Bai

Abstract

The goal for current orthopedic implant research is to design implants that have not only good biocompatibility but also antibacterial properties. TiO2 nanotubes (NTs) were fabricated on the titanium surface through electrochemical anodization, which added new properties, such as enhanced biocompatibility and potential utility as drug nanoreservoirs. The aim of the present study was to investigate the antibacterial properties and biocompatibility of NTs loaded with vancomycin (NT-V), both in vitro and in vivo. Staphylococcus aureus was used to study the antibacterial properties of the NT-V. There were three study groups: the commercially pure titanium (Cp-Ti) group, the NT group (nonloaded vancomycin), and the NT-V group. We compared NT-V biocompatibility and antibacterial efficacy with those of the NT and Cp-Ti groups. Compared with Cp-Ti, NT-V showed good antibacterial effect both in vitro and in vivo. Although the NTs reduced the surface bacterial adhesion in vitro, implant infection still developed in in vivo studies. Furthermore, the results also revealed that both NTs and NT-V showed good biocompatibility. Therefore, the NTs loaded with antibiotic might be potentially used for future orthopedic implants.

Twitter Demographics

The data shown below were collected from the profiles of 3 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 61 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 61 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 16 26%
Student > Ph. D. Student 10 16%
Researcher 9 15%
Student > Postgraduate 4 7%
Student > Doctoral Student 4 7%
Other 6 10%
Unknown 12 20%
Readers by discipline Count As %
Engineering 9 15%
Materials Science 9 15%
Chemistry 6 10%
Medicine and Dentistry 5 8%
Agricultural and Biological Sciences 4 7%
Other 10 16%
Unknown 18 30%

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 08 November 2013.
All research outputs
#2,118,245
of 4,505,915 outputs
Outputs from International Journal of Nanomedicine
#493
of 1,146 outputs
Outputs of similar age
#46,372
of 104,334 outputs
Outputs of similar age from International Journal of Nanomedicine
#71
of 97 outputs
Altmetric has tracked 4,505,915 research outputs across all sources so far. This one is in the 49th percentile – i.e., 49% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,146 research outputs from this source. They receive a mean Attention Score of 2.0. This one is in the 49th percentile – i.e., 49% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 104,334 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 51% of its contemporaries.
We're also able to compare this research output to 97 others from the same source and published within six weeks on either side of this one. This one is in the 23rd percentile – i.e., 23% of its contemporaries scored the same or lower than it.