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Magnetic nanoparticles of Fe3O4 enhance docetaxel-induced prostate cancer cell death

Overview of attention for article published in International Journal of Nanomedicine, August 2013
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Title
Magnetic nanoparticles of Fe3O4 enhance docetaxel-induced prostate cancer cell death
Published in
International Journal of Nanomedicine, August 2013
DOI 10.2147/ijn.s40766
Pubmed ID
Authors

Masatoshi Watanabe, Sato, Itcho, Ishiguro, Kawai, Kasai, Kurioka, Uemura, Kubota, Kobayashi, Okamoto

Abstract

Docetaxel (DTX) is one of the most important anticancer drugs; however, the severity of its adverse effects detracts from its practical use in the clinic. Magnetic nanoparticles of Fe3O4 (MgNPs-Fe3O4) can enhance the delivery and efficacy of anticancer drugs. We investigated the effects of MgNPs-Fe3O4 or DTX alone, and in combination with prostate cancer cell growth in vitro, as well as with the mechanism underlying the cytotoxic effects. MgNPs-Fe3O4 caused dose-dependent increases in reactive oxygen species levels in DU145, PC-3, and LNCaP cells; 8-hydroxydeoxyguanosine levels were also elevated. MgNPs-Fe3O4 alone reduced the viability of LNCaP and PC-3 cells; however, MgNPs-Fe3O4 enhanced the cytotoxic effect of a low dose of DTX in all three cell lines. MgNPs-Fe3O4 also augmented the percentage of DU145 cells undergoing apoptosis following treatment with low dose DTX. Expression of nuclear transcription factor κB in DU145 was not affected by MgNPs-Fe3O4 or DTX alone; however, combined treatment suppressed nuclear transcription factor κB expression. These findings offer the possibility that MgNPs-Fe3O4-low dose DTX combination therapy may be effective in treating prostate cancer with limited adverse effects.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 37 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 37 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 11 30%
Student > Bachelor 7 19%
Researcher 4 11%
Student > Master 4 11%
Student > Doctoral Student 1 3%
Other 4 11%
Unknown 6 16%
Readers by discipline Count As %
Agricultural and Biological Sciences 8 22%
Medicine and Dentistry 5 14%
Pharmacology, Toxicology and Pharmaceutical Science 4 11%
Engineering 4 11%
Physics and Astronomy 2 5%
Other 6 16%
Unknown 8 22%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 November 2013.
All research outputs
#17,258,834
of 21,353,728 outputs
Outputs from International Journal of Nanomedicine
#2,710
of 3,565 outputs
Outputs of similar age
#227,138
of 303,335 outputs
Outputs of similar age from International Journal of Nanomedicine
#115
of 123 outputs
Altmetric has tracked 21,353,728 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,565 research outputs from this source. They receive a mean Attention Score of 4.3. This one is in the 12th percentile – i.e., 12% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 303,335 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 13th percentile – i.e., 13% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 123 others from the same source and published within six weeks on either side of this one. This one is in the 4th percentile – i.e., 4% of its contemporaries scored the same or lower than it.