| Title |
Magnetic nanoparticles of Fe3O4 enhance docetaxel-induced prostate cancer cell death
|
|---|---|
| Published in |
International Journal of Nanomedicine, August 2013
|
| DOI | 10.2147/ijn.s40766 |
| Pubmed ID | |
| Authors |
Akiko Sato, Naoki Itcho, Hitoshi Ishiguro, Daiki Okamoto, Naohito Kobayashi, Kazuaki Kawai, Hiroshi Kasai, Daisuke Kurioka, Hiroji Uemura, Yoshinobu Kubota, Masatoshi Watanabe |
| Abstract |
Docetaxel (DTX) is one of the most important anticancer drugs; however, the severity of its adverse effects detracts from its practical use in the clinic. Magnetic nanoparticles of Fe3O4 (MgNPs-Fe3O4) can enhance the delivery and efficacy of anticancer drugs. We investigated the effects of MgNPs-Fe3O4 or DTX alone, and in combination with prostate cancer cell growth in vitro, as well as with the mechanism underlying the cytotoxic effects. MgNPs-Fe3O4 caused dose-dependent increases in reactive oxygen species levels in DU145, PC-3, and LNCaP cells; 8-hydroxydeoxyguanosine levels were also elevated. MgNPs-Fe3O4 alone reduced the viability of LNCaP and PC-3 cells; however, MgNPs-Fe3O4 enhanced the cytotoxic effect of a low dose of DTX in all three cell lines. MgNPs-Fe3O4 also augmented the percentage of DU145 cells undergoing apoptosis following treatment with low dose DTX. Expression of nuclear transcription factor κB in DU145 was not affected by MgNPs-Fe3O4 or DTX alone; however, combined treatment suppressed nuclear transcription factor κB expression. These findings offer the possibility that MgNPs-Fe3O4-low dose DTX combination therapy may be effective in treating prostate cancer with limited adverse effects. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Practitioners (doctors, other healthcare professionals) | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 40 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 40 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 12 | 30% |
| Student > Bachelor | 7 | 18% |
| Researcher | 5 | 13% |
| Student > Master | 4 | 10% |
| Student > Doctoral Student | 1 | 3% |
| Other | 4 | 10% |
| Unknown | 7 | 18% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 8 | 20% |
| Medicine and Dentistry | 5 | 13% |
| Pharmacology, Toxicology and Pharmaceutical Science | 4 | 10% |
| Engineering | 4 | 10% |
| Chemistry | 3 | 8% |
| Other | 8 | 20% |
| Unknown | 8 | 20% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 November 2013.
All research outputs
#20,823,121
of 25,584,565 outputs
Outputs from International Journal of Nanomedicine
#3,113
of 4,077 outputs
Outputs of similar age
#160,283
of 210,451 outputs
Outputs of similar age from International Journal of Nanomedicine
#97
of 101 outputs
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