| Title |
Preliminary study about the possible glycemic clinical advantage in using a fixed combination of Berberis aristata and Silybum marianum standardized extracts versus only Berberis aristata in patients with type 2 diabetes
|
|---|---|
| Published in |
Clinical Pharmacology : Advances and Applications, November 2013
|
| DOI | 10.2147/cpaa.s54308 |
| Pubmed ID | |
| Authors |
Francesco Di Pierro, Pietro Putignano, Nicola Villanova, Luca Montesi, Simona Moscatiello, Giulio Marchesini |
| Abstract |
Berberine is an isoquinoline alkaloid widely used to improve the glucidic and lipidic profiles of patients with hypercholesterolemia, metabolic syndrome, and type 2 diabetes. The limitation of berberine seems to be its poor oral bioavailability, which is affected by the presence, in enterocytes, of P-glycoprotein - an active adenosine triphosphate (ATP)-consuming efflux protein that extrudes berberine into the intestinal lumen, thus limiting its absorption. According to some authors, silymarin, derived from Silybum marianum, could be considered a P-glycoprotein antagonist. |
X Demographics
The data shown below were collected from the profiles of 5 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Switzerland | 1 | 20% |
| Russia | 1 | 20% |
| Unknown | 3 | 60% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 4 | 80% |
| Practitioners (doctors, other healthcare professionals) | 1 | 20% |
Mendeley readers
The data shown below were compiled from readership statistics for 80 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| India | 1 | 1% |
| Canada | 1 | 1% |
| Mexico | 1 | 1% |
| Greece | 1 | 1% |
| United States | 1 | 1% |
| Unknown | 75 | 94% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 12 | 15% |
| Student > Ph. D. Student | 11 | 14% |
| Student > Bachelor | 9 | 11% |
| Other | 8 | 10% |
| Researcher | 7 | 9% |
| Other | 14 | 18% |
| Unknown | 19 | 24% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 13 | 16% |
| Pharmacology, Toxicology and Pharmaceutical Science | 9 | 11% |
| Biochemistry, Genetics and Molecular Biology | 8 | 10% |
| Agricultural and Biological Sciences | 7 | 9% |
| Nursing and Health Professions | 4 | 5% |
| Other | 8 | 10% |
| Unknown | 31 | 39% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 16 June 2014.
All research outputs
#14,536,007
of 25,374,647 outputs
Outputs from Clinical Pharmacology : Advances and Applications
#89
of 179 outputs
Outputs of similar age
#116,815
of 226,646 outputs
Outputs of similar age from Clinical Pharmacology : Advances and Applications
#1
of 8 outputs
Altmetric has tracked 25,374,647 research outputs across all sources so far. This one is in the 42nd percentile – i.e., 42% of other outputs scored the same or lower than it.
So far Altmetric has tracked 179 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.8. This one has gotten more attention than average, scoring higher than 50% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 226,646 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 48th percentile – i.e., 48% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 8 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them