Title |
Influenza treatment and prophylaxis with neuraminidase inhibitors: a review
|
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Published in |
Infection and Drug Resistance, November 2013
|
DOI | 10.2147/idr.s36601 |
Pubmed ID | |
Authors |
Amanda Kamali, Mark Holodniy |
Abstract |
Influenza virus is a pathogen that causes morbidity and mortality worldwide. Whereas vaccination is important for prevention of disease, given its limitations, antiviral therapy is at the forefront of treatment and also plays a role in prevention. Currently, two classes of antiviral medications, the adamantanes and the neuraminidase inhibitors, are approved for treatment. Given the resistance patterns of circulating influenza, adamantanes are not recommended. Within the US, two neuraminidase inhibitors are currently approved for both treatment and prevention, while worldwide there are four available. In this review, we will briefly discuss the epidemiology and pathology of influenza and then discuss neuraminidase inhibitors: their mechanism of action, resistance, development, and future applications. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Spain | 1 | 1% |
United States | 1 | 1% |
Unknown | 89 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 14 | 15% |
Student > Bachelor | 13 | 14% |
Student > Master | 11 | 12% |
Researcher | 10 | 11% |
Professor | 8 | 9% |
Other | 24 | 26% |
Unknown | 11 | 12% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 21 | 23% |
Agricultural and Biological Sciences | 18 | 20% |
Biochemistry, Genetics and Molecular Biology | 14 | 15% |
Chemistry | 9 | 10% |
Immunology and Microbiology | 4 | 4% |
Other | 11 | 12% |
Unknown | 14 | 15% |