Title |
Immobilized transferrin Fe3O4@SiO2 nanoparticle with high doxorubicin loading for dual-targeted tumor drug delivery
|
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Published in |
International Journal of Nanomedicine, December 2013
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DOI | 10.2147/ijn.s51745 |
Pubmed ID | |
Authors |
Wence Ding, Lin Guo |
Abstract |
Transferrin (Tf) was immobilized onto Fe3O4@SiO2 nanoparticles with high doxorubicin (DOX) loading (TfDMP), for dual targeting of cancer, by chemically coupling both Tf and DOX with dual-function magnetic nanoparticles (DMPs) using a multi-armed crosslinker, poly-L-glutamic acid. With high trapping efficiency for magnetic targeting, TfDMP exhibits a Tf receptor-targeting function. Moreover, the DOX loading percentage of TfDMP is high, and can be controlled by adjusting the reactant ratio. TfDMP presents a narrow size distribution, and is sensitive to pH for drug release. Compared with DOX-coupled DMP without Tf modification (DDMP), TfDMP exhibits enhanced uptake by Tf receptor-expressing tumor cells, and displays stronger cancer cell cytotoxicity. This study provides an efficient method for the dual-targeted delivery of therapeutic agents to tumors, with controlled low carrier toxicity and high efficiency. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 3 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Practitioners (doctors, other healthcare professionals) | 3 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 51 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 11 | 22% |
Student > Master | 9 | 18% |
Student > Bachelor | 6 | 12% |
Researcher | 6 | 12% |
Lecturer | 2 | 4% |
Other | 5 | 10% |
Unknown | 12 | 24% |
Readers by discipline | Count | As % |
---|---|---|
Chemistry | 10 | 20% |
Pharmacology, Toxicology and Pharmaceutical Science | 6 | 12% |
Materials Science | 4 | 8% |
Medicine and Dentistry | 4 | 8% |
Agricultural and Biological Sciences | 2 | 4% |
Other | 11 | 22% |
Unknown | 14 | 27% |