Title |
Cushing's syndrome: epidemiology and developments in disease management
|
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Published in |
Clinical Epidemiology, April 2015
|
DOI | 10.2147/clep.s44336 |
Pubmed ID | |
Authors |
Susmeeta T Sharma, Lynnette K Nieman, Richard A Feelders |
Abstract |
Cushing's syndrome is a rare disorder resulting from prolonged exposure to excess glucocorticoids. Early diagnosis and treatment of Cushing's syndrome is associated with a decrease in morbidity and mortality. Clinical presentation can be highly variable, and establishing the diagnosis can often be difficult. Surgery (resection of the pituitary or ectopic source of adrenocorticotropic hormone, or unilateral or bilateral adrenalectomy) remains the optimal treatment in all forms of Cushing's syndrome, but may not always lead to remission. Medical therapy (steroidogenesis inhibitors, agents that decrease adrenocorticotropic hormone levels or glucocorticoid receptor antagonists) and pituitary radiotherapy may be needed as an adjunct. A multidisciplinary approach, long-term follow-up, and treatment modalities customized to each individual are essential for optimal control of hypercortisolemia and management of comorbidities. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 50% |
Unknown | 1 | 50% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 1 | 50% |
Practitioners (doctors, other healthcare professionals) | 1 | 50% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 2 | <1% |
Unknown | 405 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Bachelor | 92 | 23% |
Student > Master | 30 | 7% |
Student > Postgraduate | 28 | 7% |
Other | 27 | 7% |
Student > Ph. D. Student | 27 | 7% |
Other | 66 | 16% |
Unknown | 137 | 34% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 156 | 38% |
Biochemistry, Genetics and Molecular Biology | 28 | 7% |
Nursing and Health Professions | 17 | 4% |
Agricultural and Biological Sciences | 17 | 4% |
Pharmacology, Toxicology and Pharmaceutical Science | 13 | 3% |
Other | 36 | 9% |
Unknown | 140 | 34% |