Title |
Curcumin exerts its antitumor activity through regulation of miR-7/Skp2/p21 in nasopharyngeal carcinoma cells
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Published in |
OncoTargets and therapy, May 2017
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DOI | 10.2147/ott.s130055 |
Pubmed ID | |
Authors |
Shaoyan Feng, Yu Wang, Rongkai Zhang, Guangwei Yang, Zibin Liang, Zhiwei Wang, Gehua Zhang |
Abstract |
Curcumin, a natural polyphenol compound, exhibits tumor suppressive activity in a wide spectrum of cancers, including nasopharyngeal carcinoma cells. However, the exact molecular mechanisms governing this tumor suppressive activity remain elusive. Multiple studies have revealed that miRNAs are critically involved in tumorigenesis, indicating that targeting miRNAs could be a therapeutic strategy for treating human cancer. In the current study, we set out to determine whether curcumin regulates miR-7 expression in nasopharyngeal carcinoma cells. We found that curcumin inhibited cell growth, induced apoptosis, retarded cell migration and invasion, and triggered cell cycle arrest in the human nasopharyngeal carcinoma cell lines CNE1 and CNE2. Importantly, we observed that curcumin upregulated the expression of miR-7 and subsequently inhibited Skp2, a direct miR-7 target. Our results identified that upregulation of miR-7 by curcumin could benefit nasopharyngeal carcinoma patients. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 1 | 33% |
United States | 1 | 33% |
Unknown | 1 | 33% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 3 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 45 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Bachelor | 13 | 29% |
Student > Ph. D. Student | 6 | 13% |
Researcher | 2 | 4% |
Student > Postgraduate | 2 | 4% |
Professor > Associate Professor | 2 | 4% |
Other | 4 | 9% |
Unknown | 16 | 36% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 14 | 31% |
Medicine and Dentistry | 3 | 7% |
Pharmacology, Toxicology and Pharmaceutical Science | 2 | 4% |
Agricultural and Biological Sciences | 2 | 4% |
Neuroscience | 2 | 4% |
Other | 6 | 13% |
Unknown | 16 | 36% |