| Title |
Clinical characteristics and outcomes of end-stage renal disease patients with self-reported pruritus symptoms
|
|---|---|
| Published in |
International Journal of Nephrology and Renovascular Disease, December 2013
|
| DOI | 10.2147/ijnrd.s52985 |
| Pubmed ID | |
| Authors |
Karthik Ramakrishnan, T Christopher Bond, Ami Claxton, Vipan C Sood, Maria Kootsikas, Wendy Agnese, Scott Sibbel |
| Abstract |
One of the most common conditions affecting end-stage renal disease (ESRD) patients undergoing hemodialysis (HD) is pruritus. Studies report that itchy and dry skin, symptoms of pruritus, affect 40%-90% of ESRD patients. Yet, in clinical practice the condition is often underdiagnosed resulting in inadequate management and an underappreciated impact on patient outcomes. Two retrospective analyses were conducted: a preliminary analysis of ESRD patients with pruritus symptoms (n=73,124) undergoing HD or peritoneal dialysis at a large dialysis provider and a subsequent detailed analysis of a homogenous subset of patients undergoing in-center HD (n=38,315). The goal was to better understand the clinical burden of pruritus as it relates to patient characteristics, quality of life, medication use, and HD compliance. This population is commonly burdened by multiple comorbidities and related polypharmaceutical management; identifying the relationship of pruritus to these ailments can help guide future research and resource allocation. The detailed analysis confirmed trends observed in the preliminary analysis: 30% reported being "moderately" to "extremely bothered" by itchiness. The HD patient population with the highest severity of self-reported pruritus also had a consistent trend in overall increased resource utilization - higher monthly doses of erythropoietin-stimulating agents (53,397.1 to 63,405.4 units) and intravenous (IV) iron (237.2 to 247.6 units) and higher use of IV antibiotics (14.1% to 20.7%), as well as poorer quality-of-life measures (25-point reductions in Burden of Disease Score and Effects on Daily Life subscales of the Kidney Disease Quality of Life-36 survey). These results highlight the need to better identify and manage ESRD patients impacted by pruritus, as this symptom is associated with negative clinical outcomes and increased resource utilization. Further studies are needed to evaluate the current economic burden of pruritus in ESRD patients and create possible options for an improved pharmacoeconomic profile in this patient population. |
Mendeley readers
The data shown below were compiled from readership statistics for 98 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Canada | 2 | 2% |
| United States | 1 | 1% |
| Australia | 1 | 1% |
| Unknown | 94 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Other | 12 | 12% |
| Student > Master | 10 | 10% |
| Researcher | 7 | 7% |
| Student > Doctoral Student | 4 | 4% |
| Student > Postgraduate | 4 | 4% |
| Other | 14 | 14% |
| Unknown | 47 | 48% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 31 | 32% |
| Nursing and Health Professions | 9 | 9% |
| Biochemistry, Genetics and Molecular Biology | 2 | 2% |
| Environmental Science | 1 | 1% |
| Unspecified | 1 | 1% |
| Other | 7 | 7% |
| Unknown | 47 | 48% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 02 January 2014.
All research outputs
#15,289,831
of 22,738,543 outputs
Outputs from International Journal of Nephrology and Renovascular Disease
#128
of 235 outputs
Outputs of similar age
#192,797
of 307,158 outputs
Outputs of similar age from International Journal of Nephrology and Renovascular Disease
#4
of 8 outputs
Altmetric has tracked 22,738,543 research outputs across all sources so far. This one is in the 22nd percentile – i.e., 22% of other outputs scored the same or lower than it.
So far Altmetric has tracked 235 research outputs from this source. They receive a mean Attention Score of 4.3. This one is in the 34th percentile – i.e., 34% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 307,158 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 27th percentile – i.e., 27% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 8 others from the same source and published within six weeks on either side of this one. This one has scored higher than 4 of them.