| Title |
Superparamagnetic iron oxide nanoparticles conjugated with epidermal growth factor (SPION–EGF) for targeting brain tumors
|
|---|---|
| Published in |
International Journal of Nanomedicine, January 2014
|
| DOI | 10.2147/ijn.s55118 |
| Pubmed ID | |
| Authors |
Maxim A Shevtsov, Boris P Nikolaev, Ludmila Y Yakovleva, Yaroslav Y Marchenko, Anatolii V Dobrodumov, Anastasiya L Mikhrina, Marina G Martynova, Olga A Bystrova, Igor V Yakovenko, Alexander M Ischenko |
| Abstract |
Superparamagnetic iron oxide nanoparticles (SPIONs) conjugated with recombinant human epidermal growth factor (SPION-EGF) were studied as a potential agent for magnetic resonance imaging contrast enhancement of malignant brain tumors. Synthesized conjugates were characterized by transmission electron microscopy, dynamic light scattering, and nuclear magnetic resonance relaxometry. The interaction of SPION-EGF conjugates with cells was analyzed in a C6 glioma cell culture. The distribution of the nanoparticles and their accumulation in tumors were assessed by magnetic resonance imaging in an orthotopic model of C6 gliomas. SPION-EGF nanosuspensions had the properties of a negative contrast agent with high coefficients of relaxation efficiency. In vitro studies of SPION-EGF nanoparticles showed high intracellular incorporation and the absence of a toxic influence on C6 cell viability and proliferation. Intravenous administration of SPION-EGF conjugates in animals provided receptor-mediated targeted delivery across the blood-brain barrier and tumor retention of the nanoparticles; this was more efficient than with unconjugated SPIONs. The accumulation of conjugates in the glioma was revealed as hypotensive zones on T2-weighted images with a twofold reduction in T2 relaxation time in comparison to unconjugated SPIONs (P<0.001). SPION-EGF conjugates provide targeted delivery and efficient magnetic resonance contrast enhancement of EGFR-overexpressing C6 gliomas. |
X Demographics
The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 3 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Practitioners (doctors, other healthcare professionals) | 3 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 119 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 2% |
| India | 1 | <1% |
| South Africa | 1 | <1% |
| Unknown | 115 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 28 | 24% |
| Researcher | 17 | 14% |
| Student > Bachelor | 16 | 13% |
| Student > Master | 15 | 13% |
| Student > Doctoral Student | 11 | 9% |
| Other | 13 | 11% |
| Unknown | 19 | 16% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 18 | 15% |
| Medicine and Dentistry | 17 | 14% |
| Engineering | 12 | 10% |
| Biochemistry, Genetics and Molecular Biology | 9 | 8% |
| Pharmacology, Toxicology and Pharmaceutical Science | 7 | 6% |
| Other | 27 | 23% |
| Unknown | 29 | 24% |
Attention Score in Context
This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 21 January 2014.
All research outputs
#16,868,837
of 25,584,565 outputs
Outputs from International Journal of Nanomedicine
#2,057
of 4,077 outputs
Outputs of similar age
#197,194
of 320,237 outputs
Outputs of similar age from International Journal of Nanomedicine
#46
of 100 outputs
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