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Targeted therapy using nanotechnology: focus on cancer

Overview of attention for article published in International Journal of Nanomedicine, January 2014
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About this Attention Score

  • Good Attention Score compared to outputs of the same age (76th percentile)
  • High Attention Score compared to outputs of the same age and source (90th percentile)

Mentioned by

twitter
3 tweeters
patent
2 patents

Citations

dimensions_citation
323 Dimensions

Readers on

mendeley
517 Mendeley
Title
Targeted therapy using nanotechnology: focus on cancer
Published in
International Journal of Nanomedicine, January 2014
DOI 10.2147/ijn.s36654
Pubmed ID
Authors

Mario Sechi, Vanna Sanna, Nicolino Pala

Abstract

Recent advances in nanotechnology and biotechnology have contributed to the development of engineered nanoscale materials as innovative prototypes to be used for biomedical applications and optimized therapy. Due to their unique features, including a large surface area, structural properties, and a long circulation time in blood compared with small molecules, a plethora of nanomaterials has been developed, with the potential to revolutionize the diagnosis and treatment of several diseases, in particular by improving the sensitivity and recognition ability of imaging contrast agents and by selectively directing bioactive agents to biological targets. Focusing on cancer, promising nanoprototypes have been designed to overcome the lack of specificity of conventional chemotherapeutic agents, as well as for early detection of precancerous and malignant lesions. However, several obstacles, including difficulty in achieving the optimal combination of physicochemical parameters for tumor targeting, evading particle clearance mechanisms, and controlling drug release, prevent the translation of nanomedicines into therapy. In spite of this, recent efforts have been focused on developing functionalized nanoparticles for delivery of therapeutic agents to specific molecular targets overexpressed on different cancer cells. In particular, the combination of targeted and controlled-release polymer nanotechnologies has resulted in a new programmable nanotherapeutic formulation of docetaxel, namely BIND-014, which recently entered Phase II clinical testing for patients with solid tumors. BIND-014 has been developed to overcome the limitations facing delivery of nanoparticles to many neoplasms, and represents a validated example of targeted nanosystems with the optimal biophysicochemical properties needed for successful tumor eradication.

Twitter Demographics

The data shown below were collected from the profiles of 3 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 517 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 3 <1%
Egypt 1 <1%
Canada 1 <1%
Italy 1 <1%
Iran, Islamic Republic of 1 <1%
Belgium 1 <1%
China 1 <1%
United States 1 <1%
Unknown 507 98%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 130 25%
Student > Master 102 20%
Student > Bachelor 70 14%
Researcher 51 10%
Student > Doctoral Student 26 5%
Other 67 13%
Unknown 71 14%
Readers by discipline Count As %
Chemistry 86 17%
Agricultural and Biological Sciences 82 16%
Biochemistry, Genetics and Molecular Biology 62 12%
Pharmacology, Toxicology and Pharmaceutical Science 46 9%
Medicine and Dentistry 43 8%
Other 106 21%
Unknown 92 18%

Attention Score in Context

This research output has an Altmetric Attention Score of 5. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 28 July 2018.
All research outputs
#3,549,368
of 13,801,769 outputs
Outputs from International Journal of Nanomedicine
#280
of 2,682 outputs
Outputs of similar age
#56,363
of 244,399 outputs
Outputs of similar age from International Journal of Nanomedicine
#11
of 121 outputs
Altmetric has tracked 13,801,769 research outputs across all sources so far. This one has received more attention than most of these and is in the 74th percentile.
So far Altmetric has tracked 2,682 research outputs from this source. They receive a mean Attention Score of 3.0. This one has done well, scoring higher than 89% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 244,399 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 76% of its contemporaries.
We're also able to compare this research output to 121 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 90% of its contemporaries.