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Photothermal therapy of cancer cells using novel hollow gold nanoflowers

Overview of attention for article published in International Journal of Nanomedicine, January 2014
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About this Attention Score

  • Above-average Attention Score compared to outputs of the same age (61st percentile)
  • Good Attention Score compared to outputs of the same age and source (68th percentile)

Mentioned by

twitter
4 tweeters

Citations

dimensions_citation
35 Dimensions

Readers on

mendeley
69 Mendeley
Title
Photothermal therapy of cancer cells using novel hollow gold nanoflowers
Published in
International Journal of Nanomedicine, January 2014
DOI 10.2147/ijn.s55800
Pubmed ID
Authors

Long Jiang, Jing Han, Jinru Li, Wenfeng Jia, Yong Tian, Liangming Yao, Xiaoqin Li

Abstract

This article presents a new strategy for fabricating large gold nanoflowers (AuNFs) that exhibit high biological safety under visible light and very strong photothermal cytotoxicity to HeLa cells under irradiation with near-infrared (NIR) light. This particular type of AuNF was constructed using vesicles produced from a multiamine head surfactant as a template followed by depositing gold nanoparticles (AuNPs) and growing their crystallites on the surface of vesicles. The localized surface plasmon-resonance spectrum of this type of AuNF can be easily modulated to the NIR region by controlling the size of the AuNFs. When the size of the AuNFs increased, biosafety under visible light improved and cytotoxicity increased under NIR irradiation. Experiments in vitro with HeLa cells and in vivo with small mice have been carried out, with promising results. The mechanism for this phenomenon is based on the hypothesis that it is difficult for larger AuNFs to enter the cell without NIR irradiation, but they enter the cell easily at the higher temperatures caused by NIR irradiation. We believe that these effects will exist in other types of noble metallic NPs and cancer cells. In addition, the affinity between AuNPs and functional biomolecules, such as aptamers and biomarkers, will make this type of AuNF a good recognition device in cancer diagnosis and therapy.

Twitter Demographics

The data shown below were collected from the profiles of 4 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 69 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 2 3%
China 1 1%
Australia 1 1%
Unknown 65 94%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 17 25%
Researcher 10 14%
Student > Master 9 13%
Student > Bachelor 7 10%
Other 5 7%
Other 10 14%
Unknown 11 16%
Readers by discipline Count As %
Chemistry 11 16%
Biochemistry, Genetics and Molecular Biology 10 14%
Agricultural and Biological Sciences 8 12%
Medicine and Dentistry 7 10%
Pharmacology, Toxicology and Pharmaceutical Science 5 7%
Other 13 19%
Unknown 15 22%

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 30 January 2014.
All research outputs
#1,924,924
of 4,507,509 outputs
Outputs from International Journal of Nanomedicine
#275
of 1,146 outputs
Outputs of similar age
#45,313
of 120,732 outputs
Outputs of similar age from International Journal of Nanomedicine
#37
of 124 outputs
Altmetric has tracked 4,507,509 research outputs across all sources so far. This one has received more attention than most of these and is in the 56th percentile.
So far Altmetric has tracked 1,146 research outputs from this source. They receive a mean Attention Score of 1.7. This one has gotten more attention than average, scoring higher than 73% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 120,732 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 61% of its contemporaries.
We're also able to compare this research output to 124 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 68% of its contemporaries.