Title |
Prognostic value of pretreatment albumin–globulin ratio in predicting long-term mortality in gastric cancer patients who underwent D2 resection
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Published in |
OncoTargets and therapy, April 2017
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DOI | 10.2147/ott.s99282 |
Pubmed ID | |
Authors |
Jianjun Liu, Shangxiang Chen, Qirong Geng, Xuechao Liu, Pengfei Kong, Youqing Zhan, Dazhi Xu |
Abstract |
Several studies have highlighted the prognostic value of the albumin-globulin ratio (AGR) in various kinds of cancers. Our study was designed to assess whether AGR is associated with the prognosis of gastric cancer patients. A total of 507 gastric cancer patients between 2005 and 2012 were included. The AGR was defined as the ratio of serum albumin to nonalbumin and calculated by the equation: albumin/(total protein - albumin). Furthermore, AGR was divided into two groups (low and high) using the X-tile software. Survival analysis stratified by AGR groups was performed. The mean survival time for each group was 36.62 months (95% CI: 33.92-39.32) for the low AGR group and 48.95 months (95% CI: 41.93-55.96, P=0.003) for the high AGR group. Patients in the high group (AGR ≥1.93) had a significantly lower 5-year mortality in comparison with the low group (AGR <1.93) (52.4% vs 78.5%, P=0.003). The high AGR group showed obviously better overall survival than the low AGR group according to Kaplan-Meier curves (P=0.003). Multivariate analysis showed that AGR was an independent predictive factor of prognosis in gastric patients. Pretreatment AGR is a significant and independent predictive factor of prognosis. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 12 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 3 | 25% |
Unspecified | 2 | 17% |
Student > Postgraduate | 2 | 17% |
Researcher | 2 | 17% |
Student > Bachelor | 1 | 8% |
Other | 1 | 8% |
Unknown | 1 | 8% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 5 | 42% |
Unspecified | 2 | 17% |
Biochemistry, Genetics and Molecular Biology | 1 | 8% |
Chemistry | 1 | 8% |
Physics and Astronomy | 1 | 8% |
Other | 0 | 0% |
Unknown | 2 | 17% |