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Choroidal atrophy in a patient with paraneoplastic retinopathy and anti-TRPM1 antibody

Overview of attention for article published in Clinical Ophthalmology, February 2014
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • Good Attention Score compared to outputs of the same age (74th percentile)
  • High Attention Score compared to outputs of the same age and source (92nd percentile)

Mentioned by

twitter
7 tweeters

Citations

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7 Dimensions

Readers on

mendeley
9 Mendeley
Title
Choroidal atrophy in a patient with paraneoplastic retinopathy and anti-TRPM1 antibody
Published in
Clinical Ophthalmology, February 2014
DOI 10.2147/opth.s55124
Pubmed ID
Authors

Shinji Ueno, Yasuki Ito, Ruka Maruko, Mineo Kondo, Hiroko Terasaki

Abstract

The purpose of this paper is to report choroidal atrophy in a patient with cancer-associated retinopathy who had autoantibodies against the transient receptor potential cation channel, subfamily M, member 1 (TRPM1). A 69-year-old man visited our clinic in July 2010 with complaints of blurred vision and night blindness in both eyes. The full-field electroretinograms were negative type, indicating ON bipolar cell dysfunction. General physical examination revealed small cell carcinoma of the lung, and Western blot of the patient's serum showed autoantibodies against TRPM1. We diagnosed this patient with cancer-associated retinopathy and retinal ON bipolar dysfunction due to anti-TRPM1 autoantibody. We followed him for more than 2 years from the initial visit and his symptoms have not changed. However, consistent with the choroidal hypopigmentation of the fundus, spectral domain optical coherence tomography showed a decrease in choroidal thickness of about one third over a 2-year follow-up period. We suggest that this case of gradually progressive choroidal atrophy was caused by the autoantibody against TRPM1 directly, because TRPM1 is expressed not only on ON bipolar cells but also on melanocytes. These findings indicate that we should be aware of choroidal thickness in patients with paraneoplastic retinopathy who have retinal ON bipolar dysfunction with the anti-TRPM1 antibody.

Twitter Demographics

The data shown below were collected from the profiles of 7 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 9 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 9 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 3 33%
Unspecified 2 22%
Other 1 11%
Student > Postgraduate 1 11%
Professor > Associate Professor 1 11%
Other 1 11%
Readers by discipline Count As %
Medicine and Dentistry 7 78%
Unspecified 2 22%

Attention Score in Context

This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 27 February 2014.
All research outputs
#993,798
of 4,507,509 outputs
Outputs from Clinical Ophthalmology
#64
of 866 outputs
Outputs of similar age
#31,642
of 124,204 outputs
Outputs of similar age from Clinical Ophthalmology
#7
of 92 outputs
Altmetric has tracked 4,507,509 research outputs across all sources so far. Compared to these this one has done well and is in the 77th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 866 research outputs from this source. They receive a mean Attention Score of 1.3. This one has done particularly well, scoring higher than 92% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 124,204 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 74% of its contemporaries.
We're also able to compare this research output to 92 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 92% of its contemporaries.