| Title |
Cognitive dysfunction in major depression and Alzheimer's disease is associated with hippocampus–prefrontal cortex dysconnectivity
|
|---|---|
| Published in |
Neuropsychiatric Disease and Treatment, June 2017
|
| DOI | 10.2147/ndt.s136122 |
| Pubmed ID | |
| Authors |
Dayalan Sampath, Monica Sathyanesan, Samuel S Newton |
| Abstract |
Cognitive dysfunction is prevalent in psychiatric disorders. Deficits are observed in multiple domains, including working memory, executive function, attention, and information processing. Disability caused by cognitive dysfunction is frequently as debilitating as the prominent emotional disturbances. Interactions between the hippocampus and the prefrontal cortex are increasingly appreciated as an important link between cognition and emotion. Recent developments in optogenetics, imaging, and connectomics can enable the investigation of this circuit in a manner that is relevant to disease pathophysiology. The goal of this review is to shed light on the contributions of this circuit to cognitive dysfunction in neuropsychiatric disorders, focusing on Alzheimer's disease and depression. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Practitioners (doctors, other healthcare professionals) | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 199 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 199 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 33 | 17% |
| Student > Master | 31 | 16% |
| Student > Bachelor | 30 | 15% |
| Researcher | 17 | 9% |
| Student > Postgraduate | 11 | 6% |
| Other | 25 | 13% |
| Unknown | 52 | 26% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 53 | 27% |
| Psychology | 25 | 13% |
| Medicine and Dentistry | 17 | 9% |
| Biochemistry, Genetics and Molecular Biology | 14 | 7% |
| Agricultural and Biological Sciences | 13 | 7% |
| Other | 21 | 11% |
| Unknown | 56 | 28% |
Attention Score in Context
This research output has an Altmetric Attention Score of 16. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 15 November 2023.
All research outputs
#2,316,506
of 25,584,565 outputs
Outputs from Neuropsychiatric Disease and Treatment
#287
of 3,120 outputs
Outputs of similar age
#42,618
of 331,010 outputs
Outputs of similar age from Neuropsychiatric Disease and Treatment
#9
of 85 outputs
Altmetric has tracked 25,584,565 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 90th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 3,120 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 10.6. This one has done particularly well, scoring higher than 90% of its peers.
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We're also able to compare this research output to 85 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 90% of its contemporaries.