| Title |
Effects of a multimodal intervention on gait and balance of subjects with progressive multiple sclerosis: a prospective longitudinal pilot study
|
|---|---|
| Published in |
Degenerative Neurological and Neuromuscular Disease, June 2017
|
| DOI | 10.2147/dnnd.s128872 |
| Pubmed ID | |
| Authors |
Babita Bisht, Warren G Darling, Emily C White, Kaitlin A White, E Torage Shivapour, M Bridget Zimmerman, Terry L Wahls |
| Abstract |
To investigate the effects of a multimodal intervention including a modified Paleolithic diet, nutritional supplements, stretching, strengthening exercises with electrical stimulation of trunk and lower limb muscles, meditation and massage on walking performance and balance of subjects with progressive multiple sclerosis (MS). Twenty subjects with mean (standard deviation) age of 51.7 (6.4) years and Expanded Disability Status Scale score of 6.2 (1) participated in a 12-month study. Assessments were completed at baseline, 3, 6, 9, and 12 months. The entire cohort did not show significant changes in any of the assessments over 12 months except higher speed of walking toward the 10 feet mark during timed up and go (TUG) test at 6 months compared with baseline (mean change 7.9 cm/s [95% confidence interval {CI}]: 0.3, 15.2; p=0.041). Sub-group analysis revealed that 50% subjects (n=10) showed decrease in TUG time from baseline to at least 3 of 4 time-points post-intervention and were considered as responders (TUG-Res), the remaining 10 subjects were considered as nonresponders (TUG-NRes). Over 12 months, TUG-Res showed decreased mean TUG time by 31% (95% CI: -52%, -2%), increased median Berg Balance Scale scores (42 to 47), 30% increase in mean timed 25-foot walk speed (>20% considered clinically significant) and increased speed of walk toward 10 feet mark during TUG by 11.6 cm/s (95% CI: -3.0, 25.9) associated with increases in step lengths and decrease in step duration. TUG-NRes showed deterioration in walking ability over 12 months. Comparison of TUG-Res and TUG-NRes showed no significant differences in adherence to intervention but better stride duration and longer step length at baseline for TUG-Res than for TUG-NRes (p<0.05). A multimodal lifestyle intervention may improve walking performance and balance in subjects with progressive MS who have mild-to-moderate gait impairment, whereas subjects with severe gait impairments may not respond to this intervention. Future trials should assess effects of this intervention in subjects with MS during early stages of the disease. |
X Demographics
The data shown below were collected from the profiles of 43 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 16 | 37% |
| Canada | 2 | 5% |
| Australia | 2 | 5% |
| South Africa | 1 | 2% |
| Brazil | 1 | 2% |
| New Zealand | 1 | 2% |
| United Kingdom | 1 | 2% |
| Unknown | 19 | 44% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 32 | 74% |
| Practitioners (doctors, other healthcare professionals) | 7 | 16% |
| Scientists | 4 | 9% |
Mendeley readers
The data shown below were compiled from readership statistics for 83 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 83 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 10 | 12% |
| Researcher | 10 | 12% |
| Student > Doctoral Student | 10 | 12% |
| Student > Bachelor | 9 | 11% |
| Student > Master | 8 | 10% |
| Other | 11 | 13% |
| Unknown | 25 | 30% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 24 | 29% |
| Nursing and Health Professions | 8 | 10% |
| Neuroscience | 5 | 6% |
| Sports and Recreations | 5 | 6% |
| Engineering | 2 | 2% |
| Other | 7 | 8% |
| Unknown | 32 | 39% |
Attention Score in Context
This research output has an Altmetric Attention Score of 35. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 04 May 2022.
All research outputs
#1,120,416
of 25,080,267 outputs
Outputs from Degenerative Neurological and Neuromuscular Disease
#5
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Outputs of similar age
#22,412
of 322,124 outputs
Outputs of similar age from Degenerative Neurological and Neuromuscular Disease
#2
of 4 outputs
Altmetric has tracked 25,080,267 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 95th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 88 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 11.1. This one has done particularly well, scoring higher than 95% of its peers.
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