Title |
FLLL32, a curcumin analog, ameliorates intestinal injury in necrotizing enterocolitis
|
---|---|
Published in |
Journal of Inflammation Research, June 2017
|
DOI | 10.2147/jir.s131051 |
Pubmed ID | |
Authors |
Jeffrey Eckert, Brian Scott, Shelley M Lawrence, Michael Ihnat, Hala Chaaban |
Abstract |
Necrotizing enterocolitis (NEC) is a devastating gastrointestinal disease that primarily affects premature infants. It is characterized by inflammation and leukocyte infiltration that can progress to intestinal necrosis, perforation, systemic inflammatory response, and death. In this study, we examined the effect of FLLL32, a curcumin analog, on an NEC-like neonatal intestinal injury model. NEC was induced in CD-1 mice pups using the Paneth cell ablation and Klebsiella infection model. Pups were divided into sham, NEC, and NEC + FLLL32 groups. At the end of the experiment, pups were euthanized; whole blood and small intestines were harvested. Intestinal inflammatory cytokine profile, in vivo intestinal permeability using serum fluorescein isothiocyanate-dextran, and histological injury scores were compared between the groups. FLLL32-treated pups had lower intestinal injury, improved intestinal permeability, and lower proinflammatory cytokine profiles compared to those in untreated pups with NEC. These results suggest that FLLL32 plays a protective role in NEC. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Australia | 1 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 12 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Bachelor | 2 | 17% |
Professor > Associate Professor | 2 | 17% |
Student > Ph. D. Student | 1 | 8% |
Student > Doctoral Student | 1 | 8% |
Researcher | 1 | 8% |
Other | 1 | 8% |
Unknown | 4 | 33% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 3 | 25% |
Pharmacology, Toxicology and Pharmaceutical Science | 1 | 8% |
Agricultural and Biological Sciences | 1 | 8% |
Nursing and Health Professions | 1 | 8% |
Immunology and Microbiology | 1 | 8% |
Other | 1 | 8% |
Unknown | 4 | 33% |