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Annual deterioration of renal function in hypertensive patients with and without diabetes

Overview of attention for article published in Vascular Health and Risk Management, June 2017
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  • Average Attention Score compared to outputs of the same age and source

Mentioned by

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1 tweeter
facebook
2 Facebook pages

Citations

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9 Dimensions

Readers on

mendeley
80 Mendeley
Title
Annual deterioration of renal function in hypertensive patients with and without diabetes
Published in
Vascular Health and Risk Management, June 2017
DOI 10.2147/vhrm.s135253
Pubmed ID
Authors

Jorge Polonia, André Azevedo, Miguel Monte, José A Silva, Susana Bertoquini

Abstract

Chronic kidney disease (CKD) complicates hypertension and diabetes. Knowledge of the deterioration rate of CKD may anticipate adjustment of therapies with renal elimination. This study evaluates the rate of annual deterioration of renal function in hypertensive patients either with type 2 diabetes (DM2) or without it (non-DM) followed for 5 years and relates it with blood pressure (BP) and glycemic control. Out of a total of 1924 patients, 1023 patients (594 non-DM and 429 DM2, 53% female, aged 62.1±10.2 years) were evaluated over 5 years for the annual evolution of renal function (estimated glomerular filtration rate [eGFR], Modification of Diet in Renal Disease) ambulatory 24-hour blood pressure and metabolic parameters, corresponding to the analysis of 2378 patient-years. DM2 and non-DM did not differ for age, mean 24-hour BP levels, nighttime BP, albuminuria, and body mass index. DM2 versus non-DM showed a higher (p<0.02) prevalence of stage 3 CKD (24.0% vs 18.0%, eGFR 30-59), stage 4 (5.4% vs 2.7%, eGFR 15-29), and stage 5 (0.8% vs 0.5%, eGFR <15). Average annual decline of eGFR was 3.3±8.2 in DM2 versus 2.4±7.7 in non-DM (p=0.12, nonsignificant). Annual changes of eGFR and of albuminuria correlated (r=0.578, p<0.001). In multivariate analysis, age, nighttime BP, double inhibition of renin angiotensin system, albuminuria, and HbA1c >8.0% in DM2 predicted the decline in eGFR. On average, 16.2% of DM2 and 13.1% of non-DM moved each year toward a more severe stage of CKD. For initial eGFR <90 mL/min/1.73 m(2), 26.4% of DM2 and 18.1% of non-DM patients showed a reduction per year >10% from the previous eGFR value (p=0.042). Progressive deterioration of renal function each year is frequent in hypertensive diabetic and non-diabetic patients. Beyond aging, this is particularly dependent on BP control particularly at nighttime, on drug therapy, and on highly abnormal glucose control.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 80 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 80 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 15 19%
Student > Bachelor 11 14%
Student > Postgraduate 10 13%
Researcher 7 9%
Student > Doctoral Student 5 6%
Other 13 16%
Unknown 19 24%
Readers by discipline Count As %
Medicine and Dentistry 36 45%
Nursing and Health Professions 16 20%
Biochemistry, Genetics and Molecular Biology 3 4%
Agricultural and Biological Sciences 2 3%
Computer Science 1 1%
Other 2 3%
Unknown 20 25%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 September 2017.
All research outputs
#9,055,992
of 11,794,606 outputs
Outputs from Vascular Health and Risk Management
#410
of 505 outputs
Outputs of similar age
#176,832
of 267,015 outputs
Outputs of similar age from Vascular Health and Risk Management
#5
of 10 outputs
Altmetric has tracked 11,794,606 research outputs across all sources so far. This one is in the 20th percentile – i.e., 20% of other outputs scored the same or lower than it.
So far Altmetric has tracked 505 research outputs from this source. They receive a mean Attention Score of 3.7. This one is in the 17th percentile – i.e., 17% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 267,015 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 27th percentile – i.e., 27% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 10 others from the same source and published within six weeks on either side of this one. This one has scored higher than 5 of them.