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New developments in the treatment of hyperammonemia: emerging use of carglumic acid

Overview of attention for article published in International Journal of General Medicine, January 2011
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About this Attention Score

  • Good Attention Score compared to outputs of the same age (74th percentile)
  • Average Attention Score compared to outputs of the same age and source

Mentioned by

twitter
2 tweeters
wikipedia
1 Wikipedia page

Citations

dimensions_citation
59 Dimensions

Readers on

mendeley
62 Mendeley
Title
New developments in the treatment of hyperammonemia: emerging use of carglumic acid
Published in
International Journal of General Medicine, January 2011
DOI 10.2147/ijgm.s10490
Pubmed ID
Authors

Luca Filippi, Patrizio Fiorini, Giancarlo la Marca, Marta Daniotti

Abstract

Hyperammonemia is a true neonatal emergency with high toxicity for the central nervous system and developmental delay. The causes of neonatal hyperammonemia are genetic defects of urea cycle enzymes, organic acidemias, lysinuric protein intolerance, hyperammonemia-hyperornithinemia- homocitrullinemia syndrome, transient hyperammonemia of the newborn, and congenital hyperinsulinism with hyperammonemia. In some of these conditions the high blood ammonia levels are due to the reduction of N-acetylglutamate, an essential cofactor necessary for the function of the urea cycle, or to the reduction of carbamoyl-phosphate synthase-I activity. In these cases, N-carbamylglutamate (carglumic acid) can be administered together with the conventional therapy. Carglumic acid is an analog of N-acetylglutamate that has a direct action on carbamoyl-phosphate synthase-I. Its effects are reactivation of the urea cycle and reduction of plasma ammonia levels. As a consequence it improves the traditional treatment, avoiding the need of hemodialysis and peritoneal dialysis. In this review we evaluate the possible field of application of carglumic acid and its effectiveness and safety.

Twitter Demographics

The data shown below were collected from the profiles of 2 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 62 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 2%
Spain 1 2%
Colombia 1 2%
Unknown 59 95%

Demographic breakdown

Readers by professional status Count As %
Researcher 13 21%
Other 10 16%
Professor > Associate Professor 8 13%
Student > Ph. D. Student 6 10%
Student > Bachelor 5 8%
Other 10 16%
Unknown 10 16%
Readers by discipline Count As %
Medicine and Dentistry 22 35%
Pharmacology, Toxicology and Pharmaceutical Science 8 13%
Agricultural and Biological Sciences 6 10%
Biochemistry, Genetics and Molecular Biology 4 6%
Psychology 3 5%
Other 6 10%
Unknown 13 21%

Attention Score in Context

This research output has an Altmetric Attention Score of 5. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 29 April 2015.
All research outputs
#6,219,753
of 22,745,803 outputs
Outputs from International Journal of General Medicine
#265
of 1,440 outputs
Outputs of similar age
#45,584
of 180,535 outputs
Outputs of similar age from International Journal of General Medicine
#6
of 12 outputs
Altmetric has tracked 22,745,803 research outputs across all sources so far. This one has received more attention than most of these and is in the 72nd percentile.
So far Altmetric has tracked 1,440 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.6. This one has done well, scoring higher than 81% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 180,535 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 74% of its contemporaries.
We're also able to compare this research output to 12 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 50% of its contemporaries.