Title |
Identification of targets and new developments in the treatment of multiple sclerosis – focus on cladribine
|
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Published in |
Drug Design, Development and Therapy, June 2010
|
DOI | 10.2147/dddt.s6627 |
Pubmed ID | |
Authors |
Clemens Warnke, Heinz Wiendl, Hans-Peter Hartung, Olaf Stüve, Bernd C Kieseier |
Abstract |
Orally available disease-modifying drugs for relapsing-remitting multiple sclerosis (MS) represent an unmet need for this chronic and debilitating disease. Among 5 currently investigated drugs at phase 3 clinical stage, promising efficacy data for fingolimod and oral cladribine have recently been published. However, benefits need to be weighed against the risks to define the role of these compounds within current treatment regimens. In this review, data on the efficacy of a promising compound, oral cladribine, are discussed and balanced with known and anticipated risks in a postmarketing era, and finally gives an outlook on the potential place of this drug in treatment algorithms for MS in the future. |
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Geographical breakdown
Country | Count | As % |
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Spain | 1 | 2% |
Uruguay | 1 | 2% |
Italy | 1 | 2% |
Unknown | 44 | 94% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 7 | 15% |
Student > Master | 6 | 13% |
Student > Ph. D. Student | 5 | 11% |
Student > Bachelor | 5 | 11% |
Other | 5 | 11% |
Other | 11 | 23% |
Unknown | 8 | 17% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 14 | 30% |
Agricultural and Biological Sciences | 8 | 17% |
Pharmacology, Toxicology and Pharmaceutical Science | 3 | 6% |
Neuroscience | 3 | 6% |
Chemistry | 2 | 4% |
Other | 5 | 11% |
Unknown | 12 | 26% |