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11C-PIB PET imaging reveals that amyloid deposition in cases with early-onset Alzheimer’s disease in the absence of known mutations retains higher levels of PIB in the basal ganglia

Overview of attention for article published in Clinical Interventions in Aging, June 2017
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (82nd percentile)
  • High Attention Score compared to outputs of the same age and source (80th percentile)

Mentioned by

news
1 news outlet
twitter
1 tweeter

Citations

dimensions_citation
8 Dimensions

Readers on

mendeley
27 Mendeley
Title
<sup>11</sup>C-PIB PET imaging reveals that amyloid deposition in cases with early-onset Alzheimer&rsquo;s disease in the absence of known mutations retains higher levels of PIB in the basal ganglia
Published in
Clinical Interventions in Aging, June 2017
DOI 10.2147/cia.s132884
Pubmed ID
Authors

Youn, Young Chul, Jang, Jae-Won, Han, Su-Hyun, Kim, HyeRyoun, Seok, Ju Won, Byun, Jun Soo, Park, Kwang-Yeol, An, Seong Soo, Chun, In Kook, Kim, SangYun

Abstract

Early-onset Alzheimer's disease (EOAD) has a different pathologic burden and clinical features compared with late-onset Alzheimer's disease (LOAD). We examined the effects of age at onset on the burden and distribution of β-amyloid in patients with EOAD, in whom well-characterized mutations associated with Alzheimer's disease were absent. We genotyped ApoE, APP, PSEN1 and PSEN2 in the patients with Alzheimer's disease: 9 patients with EOAD (age <65), 11 with LOAD (age >70) and 8 normal controls (NCs), all of whom had undergone (11)C-labeled Pittsburgh compound B-positron emission tomography imaging. Patients with EOAD exhibited higher z scores and larger cluster sizes, and retained higher levels of Pittsburgh compound B in the bilateral thalamus and in some parts of the globus pallidus (P<0.05, false discovery rate). Distribution of amyloid deposition in EOAD outside the context of genetic mutations topographically showed some differences from that in LOAD.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 27 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 27 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 4 15%
Researcher 3 11%
Professor > Associate Professor 3 11%
Student > Ph. D. Student 3 11%
Student > Bachelor 2 7%
Other 7 26%
Unknown 5 19%
Readers by discipline Count As %
Medicine and Dentistry 9 33%
Neuroscience 6 22%
Agricultural and Biological Sciences 3 11%
Psychology 1 4%
Physics and Astronomy 1 4%
Other 1 4%
Unknown 6 22%

Attention Score in Context

This research output has an Altmetric Attention Score of 10. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 21 July 2017.
All research outputs
#1,140,649
of 11,498,428 outputs
Outputs from Clinical Interventions in Aging
#169
of 1,172 outputs
Outputs of similar age
#44,705
of 261,723 outputs
Outputs of similar age from Clinical Interventions in Aging
#7
of 35 outputs
Altmetric has tracked 11,498,428 research outputs across all sources so far. Compared to these this one has done well and is in the 89th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,172 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.3. This one has done well, scoring higher than 85% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 261,723 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 82% of its contemporaries.
We're also able to compare this research output to 35 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 80% of its contemporaries.