| Title |
Adverse reactions in leprosy patients who underwent dapsone multidrug therapy: a retrospective study
|
|---|---|
| Published in |
Clinical Pharmacology : Advances and Applications, June 2017
|
| DOI | 10.2147/cpaa.s135846 |
| Pubmed ID | |
| Authors |
Sanjeev Guragain, Namrata Upadhayay, Bishwa Mohan Bhattarai |
| Abstract |
To investigate the occurrence and clinical characteristics of dapsone-related adverse drug reactions (ADRs) among leprosy patients who underwent multidrug therapy (MDT) from 2010 to 2013 in the western region of Nepal. A retrospective review was carried out in the rehabilitation center. Data were collected from the record files of the hospital. From 2010 to 2013, there were 18 patients reported to have dapsone ADRs, with an occurrence rate of 0.82% in the 4-year duration. The maximum incidence of ADRs (1.043%) was in 2010 and the minimum incidence of ADRs (0.26%) was in 2013. Among two types of bacterial infections, 94.44% were of multibacillary and 5.56% were of paucibacillary type. The age range of patients with dapsone ADRs was 11-68 years. The male-to-female ratio was 1.25. The onset of dapsone ADRs after taking MDT was within a minimum of 3 weeks and a maximum of 21 weeks. There were 14 (77.77%) patients who presented with jaundice, 8 (44.44%) with exfoliative dermatitis, 5 (27.77%) with hemolytic anemia and 4 (22.22%) with fever and headache. The rare side effects (5.5%) found were agranulocytosis or toxic epidermal necrolysis. Three patients were cured; some were still on the treatment. Four patients died with dapsone ADRs. The common dapsone ADRs present in leprosy patients were jaundice, exfoliative dermatitis and hemolytic anemia in MDT-treated patients. Patients could be cured by managing the dapsone ADRs effectively on time. Some patients may die of dapsone ADRs if clinicians fail to manage the side effects on time. |
X Demographics
The data shown below were collected from the profiles of 4 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Germany | 1 | 25% |
| Unknown | 3 | 75% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 4 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 95 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 95 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 17 | 18% |
| Student > Master | 16 | 17% |
| Student > Bachelor | 13 | 14% |
| Other | 6 | 6% |
| Student > Ph. D. Student | 5 | 5% |
| Other | 12 | 13% |
| Unknown | 26 | 27% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 30 | 32% |
| Nursing and Health Professions | 8 | 8% |
| Pharmacology, Toxicology and Pharmaceutical Science | 8 | 8% |
| Biochemistry, Genetics and Molecular Biology | 6 | 6% |
| Agricultural and Biological Sciences | 2 | 2% |
| Other | 12 | 13% |
| Unknown | 29 | 31% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 14 August 2017.
All research outputs
#14,605,790
of 25,382,440 outputs
Outputs from Clinical Pharmacology : Advances and Applications
#90
of 179 outputs
Outputs of similar age
#162,521
of 330,503 outputs
Outputs of similar age from Clinical Pharmacology : Advances and Applications
#3
of 5 outputs
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So far Altmetric has tracked 179 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.8. This one is in the 48th percentile – i.e., 48% of its peers scored the same or lower than it.
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