Title |
Fluconazole resistance in Candida species: a current perspective
|
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Published in |
Infection and Drug Resistance, July 2017
|
DOI | 10.2147/idr.s118892 |
Pubmed ID | |
Authors |
Elizabeth L Berkow, Shawn R Lockhart |
Abstract |
Candida albicans and the emerging non-albicans Candida spp. have significant clinical relevance among many patient populations. Current treatment guidelines include fluconazole as a primary therapeutic option for the treatment of these infections, but it is only fungistatic against Candida spp. and both inherent and acquired resistance to fluconazole have been reported. Such mechanisms of resistance include increased drug efflux, alteration or increase in the drug target, and development of compensatory pathways for producing the target sterol, ergosterol. While many mechanisms of resistance observed in C. albicans are also found in the non-albicans species, there are also important and unexpected differences between species. Furthermore, mechanisms of fluconazole resistance in emerging Candida spp., including the global health threat Candida auris, are largely unknown. In order to preserve the utility of one of our fundamental antifungal drugs, fluconazole, it is essential that we fully appreciate the manner by which Candida spp. manifest resistance to it. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 3 | 38% |
Netherlands | 2 | 25% |
United Kingdom | 1 | 13% |
Unknown | 2 | 25% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Scientists | 4 | 50% |
Members of the public | 3 | 38% |
Practitioners (doctors, other healthcare professionals) | 1 | 13% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 531 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Bachelor | 74 | 14% |
Student > Master | 61 | 11% |
Student > Ph. D. Student | 41 | 8% |
Researcher | 29 | 5% |
Other | 21 | 4% |
Other | 77 | 15% |
Unknown | 228 | 43% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 62 | 12% |
Immunology and Microbiology | 60 | 11% |
Medicine and Dentistry | 49 | 9% |
Agricultural and Biological Sciences | 41 | 8% |
Pharmacology, Toxicology and Pharmaceutical Science | 28 | 5% |
Other | 52 | 10% |
Unknown | 239 | 45% |