| Title |
Exploring cellular uptake of iron oxide nanoparticles associated with rhodium citrate in breast cancer cells
|
|---|---|
| Published in |
International Journal of Nanomedicine, August 2017
|
| DOI | 10.2147/ijn.s141582 |
| Pubmed ID | |
| Authors |
Natalia L Chaves, Irina Estrela-Lopis, Julia Böttner, Cláudio AP Lopes, Bruna C Guido, Aparecido R de Sousa, Sônia N Báo |
| Abstract |
Nanocarriers have the potential to improve the therapeutic index of currently available drugs by improving their efficacy and achieving therapeutic steady-state levels over an extended period. The association of maghemite-rhodium citrate (MRC) nanoparticles (NPs) has the potential to increase specificity of the cytotoxic action. However, the interaction of these NPs with cells, their uptake mechanism, and subcellular localization need to be elucidated. This work evaluates the uptake mechanism of MRC NPs in metastatic and nonmetastatic breast cancer-cell models, comparing them to a nontumor cell line. MRC NPs uptake in breast cancer cells was more effective than in normal cells, with regard to both the amount of internalized material and the achievement of more strategic intracellular distribution. Moreover, this process occurred through a clathrin-dependent endocytosis pathway with different basal expression levels of this protein in the cell lines tested. |
Mendeley readers
The data shown below were compiled from readership statistics for 66 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 66 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 21 | 32% |
| Student > Master | 12 | 18% |
| Student > Bachelor | 6 | 9% |
| Researcher | 5 | 8% |
| Professor > Associate Professor | 2 | 3% |
| Other | 7 | 11% |
| Unknown | 13 | 20% |
| Readers by discipline | Count | As % |
|---|---|---|
| Chemistry | 13 | 20% |
| Biochemistry, Genetics and Molecular Biology | 12 | 18% |
| Pharmacology, Toxicology and Pharmaceutical Science | 6 | 9% |
| Agricultural and Biological Sciences | 5 | 8% |
| Materials Science | 5 | 8% |
| Other | 11 | 17% |
| Unknown | 14 | 21% |