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Synergistic interactions between antimicrobial peptides derived from plectasin and lipid nanocapsules containing monolaurin as a cosurfactant against Staphylococcus aureus

Overview of attention for article published in International Journal of Nanomedicine, August 2017
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Mentioned by

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1 tweeter

Citations

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26 Dimensions

Readers on

mendeley
54 Mendeley
Title
Synergistic interactions between antimicrobial peptides derived from plectasin and lipid nanocapsules containing monolaurin as a cosurfactant against <em>Staphylococcus aureus</em>
Published in
International Journal of Nanomedicine, August 2017
DOI 10.2147/ijn.s139625
Pubmed ID
Authors

Anita Umerska, Viviane Cassisa, Guillaume Bastiat, Nada Matougui, Hassan Nehme, Florence Manero, Matthieu Eveillard, Patrick Saulnier

Abstract

Development of effective antibacterial agents for the treatment of infections caused by Gram-positive bacteria resistant to existing antibiotics, such as methicillin-resistant Staphylococcus aureus (MRSA), is an area of intensive research. In this work, the antibacterial efficacy of two antimicrobial peptides derived from plectasin, AP114 and AP138, used alone and in combination with monolaurin-lipid nanocapsules (ML-LNCs) was evaluated. Several interesting findings emerged from the present study. First, ML-LNCs and both plectasin derivatives showed potent activity against all 14 tested strains of S. aureus, independent of their resistance phenotype. Both peptides displayed a considerable adsorption (33%-62%) onto ML-LNCs without having an important impact on the particle properties such as size. The combinations of peptide with ML-LNC displayed synergistic effect against S. aureus, as confirmed by two methods: checkerboard and time-kill assays. This synergistic interaction enables a dose reduction and consequently decreases the risk of toxicity and has the potential of minimizing the development of resistance. Together, these results suggest that ML-LNCs loaded with a plectasin derivative may be a very promising drug delivery system for further development as a novel antibacterial agent against S. aureus, including MRSA.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 54 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 54 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 9 17%
Student > Ph. D. Student 7 13%
Professor > Associate Professor 6 11%
Researcher 4 7%
Student > Master 4 7%
Other 9 17%
Unknown 15 28%
Readers by discipline Count As %
Pharmacology, Toxicology and Pharmaceutical Science 9 17%
Biochemistry, Genetics and Molecular Biology 7 13%
Medicine and Dentistry 5 9%
Agricultural and Biological Sciences 4 7%
Chemistry 4 7%
Other 10 19%
Unknown 15 28%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 16 August 2017.
All research outputs
#7,236,242
of 11,618,931 outputs
Outputs from International Journal of Nanomedicine
#1,345
of 2,298 outputs
Outputs of similar age
#137,575
of 238,482 outputs
Outputs of similar age from International Journal of Nanomedicine
#26
of 54 outputs
Altmetric has tracked 11,618,931 research outputs across all sources so far. This one is in the 23rd percentile – i.e., 23% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,298 research outputs from this source. They receive a mean Attention Score of 3.0. This one is in the 27th percentile – i.e., 27% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 238,482 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 32nd percentile – i.e., 32% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 54 others from the same source and published within six weeks on either side of this one. This one is in the 33rd percentile – i.e., 33% of its contemporaries scored the same or lower than it.