Title |
Liposomal curcumin and its application in cancer
|
---|---|
Published in |
International Journal of Nanomedicine, August 2017
|
DOI | 10.2147/ijn.s132434 |
Pubmed ID | |
Authors |
Ting Feng, Yumeng Wei, Robert J Lee, Ling Zhao |
Abstract |
Curcumin (CUR) is a yellow polyphenolic compound derived from the plant turmeric. It is widely used to treat many types of diseases, including cancers such as those of lung, cervices, prostate, breast, bone and liver. However, its effectiveness has been limited due to poor aqueous solubility, low bioavailability and rapid metabolism and systemic elimination. To solve these problems, researchers have tried to explore novel drug delivery systems such as liposomes, solid dispersion, microemulsion, micelles, nanogels and dendrimers. Among these, liposomes have been the most extensively studied. Liposomal CUR formulation has greater growth inhibitory and pro-apoptotic effects on cancer cells. This review mainly focuses on the preparation of liposomes containing CUR and its use in cancer therapy. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 11 | 19% |
Turkey | 4 | 7% |
India | 1 | 2% |
Spain | 1 | 2% |
Germany | 1 | 2% |
Australia | 1 | 2% |
Pakistan | 1 | 2% |
United Kingdom | 1 | 2% |
France | 1 | 2% |
Other | 2 | 3% |
Unknown | 34 | 59% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 50 | 86% |
Practitioners (doctors, other healthcare professionals) | 6 | 10% |
Scientists | 2 | 3% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 363 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 48 | 13% |
Student > Ph. D. Student | 39 | 11% |
Student > Bachelor | 39 | 11% |
Researcher | 28 | 8% |
Professor > Associate Professor | 14 | 4% |
Other | 53 | 15% |
Unknown | 142 | 39% |
Readers by discipline | Count | As % |
---|---|---|
Pharmacology, Toxicology and Pharmaceutical Science | 53 | 15% |
Biochemistry, Genetics and Molecular Biology | 41 | 11% |
Medicine and Dentistry | 23 | 6% |
Chemistry | 19 | 5% |
Agricultural and Biological Sciences | 16 | 4% |
Other | 52 | 14% |
Unknown | 159 | 44% |