| Title |
Platelet distribution width as a prognostic factor in patients with COPD – pilot study
|
|---|---|
| Published in |
International Journal of Chronic Obstructive Pulmonary Disease, August 2017
|
| DOI | 10.2147/copd.s131868 |
| Pubmed ID | |
| Authors |
Adam J Białas, Claudio Pedone, Wojciech J Piotrowski, Raffaele Antonelli Incalzi |
| Abstract |
Platelets may actively participate in inflammation in COPD. Platelet distribution width (PDW), a measure of platelets' volume heterogeneity, may increase in platelets' activation. We hypothesized that PDW may be a marker of hypercoagulation, which plays a significant role in conditions associated with worse survival of patients with COPD, eg, acute myocardial infarction and other forms of ischemic heart disease. Retrospective analysis of 79 patients. Variables were compared after grouping patients according to the upper normal limit of PDW, using Welch's t-tests or Mann-Whitney U, and chi-square tests. Survival in the two groups was compared using the Kaplan-Meier method and Cox proportional hazards regression. Ten patients presented values of PDW above 16 fL, which was the upper limit of normality for our laboratory. Compared to patients with normal PDW, they had lower forced expiratory flow between 25% and 75% of vital capacity (FEF 25-75) - 35% of reference value vs 57% (P=0.003) and peak expiratory flow - 39% vs 54% (P<0.001). The median survival of patients with elevated PDW was 743 days compared to those with normal PDW (1,305 days) (P=0.025). The adjusted HR was 4.59 (95% CI: 1.1, 19.19; P=0.04). Our analysis indicates that elevated PDW is associated with reduced survival of patients with COPD. If our data are to be confirmed, PDW may be used as an inexpensive and repeatable prognostic tool in COPD. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Spain | 1 | 50% |
| Unknown | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 24 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 24 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Postgraduate | 5 | 21% |
| Student > Ph. D. Student | 3 | 13% |
| Researcher | 2 | 8% |
| Student > Doctoral Student | 1 | 4% |
| Student > Bachelor | 1 | 4% |
| Other | 4 | 17% |
| Unknown | 8 | 33% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 9 | 38% |
| Nursing and Health Professions | 3 | 13% |
| Pharmacology, Toxicology and Pharmaceutical Science | 1 | 4% |
| Unknown | 11 | 46% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 May 2018.
All research outputs
#19,951,180
of 25,382,440 outputs
Outputs from International Journal of Chronic Obstructive Pulmonary Disease
#1,938
of 2,578 outputs
Outputs of similar age
#238,297
of 327,503 outputs
Outputs of similar age from International Journal of Chronic Obstructive Pulmonary Disease
#57
of 78 outputs
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