Title |
Factors associated with plasma IL-33 levels in patients with chronic obstructive pulmonary disease
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Published in |
International Journal of Chronic Obstructive Pulmonary Disease, January 2017
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DOI | 10.2147/copd.s120445 |
Pubmed ID | |
Authors |
Sei Won Kim, Chin Kook Rhee, Ki Uk Kim, Sang Haak Lee, Hun Gyu Hwang, Yu Il Kim, Deog Kyeom Kim, Sang Do Lee, Yeon-Mok Oh, Hyoung Kyu Yoon |
Abstract |
Interleukin (IL)-33 promotes T helper (Th)2 immunity and systemic inflammation. The role of IL-33 in asthma has been widely investigated. IL-33 has also been suggested to play an important role in the pathogenesis of chronic obstructive pulmonary disease (COPD). This study investigated the clinical significance and usefulness of plasma IL-33 level in patients with COPD. A total of 307 patients with stable COPD from 15 centers, who were in the Korean Obstructive Lung Disease cohort, were enrolled in this study. Plasma IL-33 levels were measured by enzyme-linked immunosorbent assay. We analyzed the association between IL-33 level and other clinical characteristics related to COPD. We also examined the features of patients with COPD who exhibited high IL-33 levels. IL-33 levels varied, but were very low in most patients. Eosinophil count was significantly correlated with a plasma IL-33 level. In addition, old age and current smoking were related to a low IL-33 level. Significantly more patients with a higher IL-33 level had chronic bronchitis compared with those with a low IL-33 level. Plasma IL-33 level in patients with stable COPD was related to eosinophil count and chronic bronchitis phenotype. Further studies are needed to identify the precise mechanisms of IL-33/ST2 pathway in patients with COPD. |
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United States | 1 | 100% |
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Mendeley readers
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Unknown | 25 | 100% |
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Researcher | 5 | 20% |
Student > Master | 4 | 16% |
Student > Postgraduate | 2 | 8% |
Student > Ph. D. Student | 1 | 4% |
Other | 1 | 4% |
Other | 2 | 8% |
Unknown | 10 | 40% |
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Computer Science | 1 | 4% |
Other | 0 | 0% |
Unknown | 9 | 36% |