| Title |
Effects of daily vitamin D supplementation on respiratory muscle strength and physical performance in vitamin D-deficient COPD patients: a pilot trial
|
|---|---|
| Published in |
International Journal of Chronic Obstructive Pulmonary Disease, August 2017
|
| DOI | 10.2147/copd.s132117 |
| Pubmed ID | |
| Authors |
Rachida Rafiq, Hendrik J Prins, Wim G Boersma, Johannes MA Daniels, Martin den Heijer, Paul Lips, Renate T de Jongh |
| Abstract |
Although vitamin D is well known for its function in calcium homeostasis and bone mineralization, several studies have shown positive effects on muscle strength and physical function. In addition, vitamin D has been associated with pulmonary function and the incidence of airway infections. As vitamin D deficiency is highly prevalent in chronic obstructive pulmonary disease (COPD) patients, supplementation might have a beneficial effect in these patients. To assess the effect of vitamin D supplementation on respiratory muscle strength and physical performance in vitamin D-deficient COPD patients. Secondary outcomes are pulmonary function, handgrip strength, exacerbation rate, and quality of life. We performed a randomized, double-blind, placebo-controlled pilot trial. Participants were randomly allocated to receive 1,200 IU vitamin D3 per day (n=24) or placebo (n=26) during 6 months. Study visits were conducted at baseline, and at 3 and 6 months after randomization. During the visits, blood was collected, respiratory muscle strength was measured (maximum inspiratory and expiratory pressure), physical performance and 6-minute walking tests were performed, and handgrip strength and pulmonary function were assessed. In addition, participants kept a diary card in which they registered respiratory symptoms. At baseline, the mean (standard deviation [SD]) serum 25-hydroxyvitamin D (25(OH)D) concentration (nmol/L) was 42.3 (15.2) in the vitamin D group and 40.6 (17.0) in the placebo group. Participants with vitamin D supplementation had a larger increase in serum 25(OH)D compared to the placebo group after 6 months (mean difference (SD): +52.8 (29.8) vs +12.3 (25.1), P<0.001). Primary outcomes, respiratory muscle strength and physical performance, did not differ between the groups after 6 months. In addition, no differences were found in the 6-minute walking test results, handgrip strength, pulmonary function, exacerbation rate, or quality of life. Vitamin D supplementation did not affect (respiratory) muscle strength or physical performance in this pilot trial in vitamin D-deficient COPD patients. |
X Demographics
The data shown below were collected from the profiles of 17 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 3 | 18% |
| Netherlands | 3 | 18% |
| United States | 2 | 12% |
| Australia | 2 | 12% |
| Brazil | 2 | 12% |
| Venezuela, Bolivarian Republic of | 1 | 6% |
| Unknown | 4 | 24% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 9 | 53% |
| Scientists | 5 | 29% |
| Practitioners (doctors, other healthcare professionals) | 3 | 18% |
Mendeley readers
The data shown below were compiled from readership statistics for 165 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 165 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 25 | 15% |
| Student > Bachelor | 25 | 15% |
| Student > Ph. D. Student | 13 | 8% |
| Researcher | 6 | 4% |
| Lecturer | 6 | 4% |
| Other | 18 | 11% |
| Unknown | 72 | 44% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 38 | 23% |
| Nursing and Health Professions | 22 | 13% |
| Biochemistry, Genetics and Molecular Biology | 9 | 5% |
| Sports and Recreations | 7 | 4% |
| Agricultural and Biological Sciences | 4 | 2% |
| Other | 11 | 7% |
| Unknown | 74 | 45% |
Attention Score in Context
This research output has an Altmetric Attention Score of 11. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 26 September 2017.
All research outputs
#3,359,389
of 25,584,565 outputs
Outputs from International Journal of Chronic Obstructive Pulmonary Disease
#397
of 2,571 outputs
Outputs of similar age
#58,255
of 328,005 outputs
Outputs of similar age from International Journal of Chronic Obstructive Pulmonary Disease
#12
of 78 outputs
Altmetric has tracked 25,584,565 research outputs across all sources so far. Compared to these this one has done well and is in the 86th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,571 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.5. This one has done well, scoring higher than 84% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 328,005 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 82% of its contemporaries.
We're also able to compare this research output to 78 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 85% of its contemporaries.