Title |
iRGD-modified lipid–polymer hybrid nanoparticles loaded with isoliquiritigenin to enhance anti-breast cancer effect and tumor-targeting ability
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Published in |
International Journal of Nanomedicine, June 2017
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DOI | 10.2147/ijn.s134148 |
Pubmed ID | |
Authors |
Fei Gao, Jinming Zhang, Chaomei Fu, Xiaoming Xie, Fu Peng, Jieshu You, Hailin Tang, Zhiyu Wang, Peng Li, Jianping Chen |
Abstract |
Isoliquiritigenin (ISL), a natural anti-breast cancer dietary compound, has poor delivery characteristics and low bioavailability. In order to promote the therapeutic outcome of ISL, a tumor-targeting lipid-polymer hybrid nanoparticle (NP) system modified by tumor-homing iRGD peptides has been developed. The hybrid NPs were prepared by a modified single-step nanoprecipitation method to encapsulate ISL. iRGD peptides were anchored on the surface by a postinsertion method (ISL-iRGD NPs). The stable lipid-polymer structure of ISL-iRGD NPs, with high encapsulation and loading efficiency, was confirmed. Compared to free ISL and non-iRGD-modified counterparts, ISL-iRGD NPs showed higher cytotoxicity and cell apoptosis against the different type of breast cancer cells. This was attributable to higher cellular accumulation mediated by the iRGD-integrin recognition and the nanoscale effect. More importantly, based on the active tumor-tissue accumulation by iRGD peptides and the prolonged in vivo circulation by the stealth nanostructure, ISL-iRGD NPs displayed higher tumor-growth inhibition efficiency in 4T1-bearing breast-tumor mouse models. Therefore, the constructed iRGD modified lipid-polymer hybrid NPs would provide a promising drug-delivery strategy to improve ISL in anti-breast cancer efficacy. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 81 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 13 | 16% |
Student > Master | 13 | 16% |
Researcher | 7 | 9% |
Student > Doctoral Student | 7 | 9% |
Other | 6 | 7% |
Other | 15 | 19% |
Unknown | 20 | 25% |
Readers by discipline | Count | As % |
---|---|---|
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Medicine and Dentistry | 9 | 11% |
Biochemistry, Genetics and Molecular Biology | 5 | 6% |
Chemistry | 5 | 6% |
Agricultural and Biological Sciences | 3 | 4% |
Other | 10 | 12% |
Unknown | 28 | 35% |