Title |
A case of schizophrenia comorbid for tetralogy of Fallot treated with clozapine: further considerations on a role for 22q.11.2 in the proneness for seizures
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Published in |
Neuropsychiatric Disease and Treatment, August 2017
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DOI | 10.2147/ndt.s144212 |
Pubmed ID | |
Authors |
Hiroko Kashiwagi, Satoru Ikezawa, Tomiki Sumiyoshi, Atsuko Kadono, Kazuhiko Segawa, Kazuyoshi Takeda, Mayu Omori, Hisako Taguchi, Naotsugu Hirabayashi |
Abstract |
We present a case of schizophrenia comorbid for tetralogy of Fallot, without chromosome 22q.11.2 deletion or duplication, treated successfully with a combination of clozapine and antiepileptic drugs. Although clozapine by itself initially triggered convulsive seizures, we continued it with co-administration of valproate and topiramate. This combined treatment did not affect cardiac function of the patient, who experienced a favorable clinical course in terms of symptomatology and functional outcomes. To our knowledge, we provide the first report on a patient with tetralogy of Fallot, in whom 22q.11.2 was not deleted and clozapine-induced seizures were observed. |
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Unknown | 1 | 100% |
Demographic breakdown
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 24 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Bachelor | 4 | 17% |
Other | 3 | 13% |
Student > Doctoral Student | 2 | 8% |
Researcher | 2 | 8% |
Student > Master | 2 | 8% |
Other | 2 | 8% |
Unknown | 9 | 38% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 5 | 21% |
Neuroscience | 2 | 8% |
Psychology | 2 | 8% |
Biochemistry, Genetics and Molecular Biology | 1 | 4% |
Sports and Recreations | 1 | 4% |
Other | 1 | 4% |
Unknown | 12 | 50% |