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Development of a core outcome set for medication review in older patients with multimorbidity and polypharmacy: a study protocol

Overview of attention for article published in Clinical Interventions in Aging, August 2017
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Title
Development of a core outcome set for medication review in older patients with multimorbidity and polypharmacy: a study protocol
Published in
Clinical Interventions in Aging, August 2017
DOI 10.2147/cia.s135481
Pubmed ID
Authors

Jean-Baptiste Beuscart, Olivia Dalleur, Benoit Boland, Stefanie Thevelin, Wilma Knol, Shane Cullinan, Claudio Schneider, Denis O'Mahony, Nicolas Rodondi, Anne Spinewine

Abstract

Medication review has been advocated to address the challenge of polypharmacy in older patients, yet there is no consensus on how best to evaluate its efficacy. Heterogeneity of outcomes reported in clinical trials can hinder the comparison of clinical trial findings in systematic reviews. Moreover, the outcomes that matter most to older patients might be under-reported or disregarded altogether. A core outcome set can address this issue as it defines a minimum set of outcomes that should be reported in all clinical trials in any particular field of research. As part of the European Commission-funded project, called OPtimising thERapy to prevent Avoidable hospital admissions in the Multimorbid elderly, this paper describes the methods used to develop a core outcome set for clinical trials of medication review in older patients with multimorbidity. The study was designed in several steps. First, a systematic review established which outcomes were measured in published and ongoing clinical trials of medication review in older patients. Second, we undertook semistructured interviews with older patients and carers aimed at identifying additional relevant outcomes. Then, a multilanguage European Delphi survey adapted to older patients was designed. The international Delphi survey was conducted with older patients, health care professionals, researchers, and clinical experts in geriatric pharmacotherapy to validate outcomes to be included in the core outcome set. Consensus meetings were conducted to validate the results. We present the method for developing a core outcome set for medication review in older patients with multimorbidity. This study protocol could be used as a basis to develop core outcome sets in other fields of geriatric research.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 68 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 68 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 14 21%
Researcher 12 18%
Student > Doctoral Student 7 10%
Student > Ph. D. Student 6 9%
Other 4 6%
Other 11 16%
Unknown 14 21%
Readers by discipline Count As %
Medicine and Dentistry 20 29%
Pharmacology, Toxicology and Pharmaceutical Science 10 15%
Social Sciences 4 6%
Psychology 4 6%
Nursing and Health Professions 3 4%
Other 7 10%
Unknown 20 29%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 September 2017.
All research outputs
#9,378,376
of 11,732,910 outputs
Outputs from Clinical Interventions in Aging
#965
of 1,190 outputs
Outputs of similar age
#193,671
of 264,300 outputs
Outputs of similar age from Clinical Interventions in Aging
#42
of 44 outputs
Altmetric has tracked 11,732,910 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,190 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.3. This one is in the 6th percentile – i.e., 6% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 264,300 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 15th percentile – i.e., 15% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 44 others from the same source and published within six weeks on either side of this one. This one is in the 4th percentile – i.e., 4% of its contemporaries scored the same or lower than it.