| Title |
Intensity modulated radiation therapy for breast cancer: current perspectives
|
|---|---|
| Published in |
Breast cancer targets and therapy, March 2017
|
| DOI | 10.2147/bctt.s113025 |
| Pubmed ID | |
| Authors |
Milly Buwenge, Silvia Cammelli, Ilario Ammendolia, Giorgio Tolento, Alice Zamagni, Alessandra Arcelli, Gabriella Macchia, Francesco Deodato, Savino Cilla, Alessio G Morganti |
| Abstract |
Owing to highly conformed dose distribution, intensity modulated radiation therapy (IMRT) has the potential to improve treatment results of radiotherapy (RT). Postoperative RT is a standard adjuvant treatment in conservative treatment of breast cancer (BC). The aim of this review is to analyze available evidence from randomized controlled trials (RCTs) on IMRT in BC, particularly in terms of reduction of side effects. A literature search of the bibliographic database PubMed, from January 1990 through November 2016, was performed. Only RCTs published in English were included. Ten articles reporting data from 5 RCTs fulfilled the selection criteria and were included in our review. Three out of 5 studies enrolled only selected patients in terms of increased risk of toxicity. Three studies compared IMRT with standard tangential RT. One study compared the results of IMRT in the supine versus the prone position, and one study compared standard treatment with accelerated partial breast IMRT. Three studies reported reduced acute and/or late toxicity using IMRT compared with standard RT. No study reported improved quality of life. IMRT seems able to reduce toxicity in selected patients treated with postoperative RT for BC. Further analyses are needed to better define patients who are candidates for this treatment modality. |
Mendeley readers
The data shown below were compiled from readership statistics for 72 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Slovenia | 1 | 1% |
| Unknown | 71 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 10 | 14% |
| Other | 9 | 13% |
| Student > Master | 8 | 11% |
| Researcher | 7 | 10% |
| Student > Ph. D. Student | 6 | 8% |
| Other | 12 | 17% |
| Unknown | 20 | 28% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 25 | 35% |
| Nursing and Health Professions | 7 | 10% |
| Physics and Astronomy | 5 | 7% |
| Biochemistry, Genetics and Molecular Biology | 4 | 6% |
| Computer Science | 3 | 4% |
| Other | 5 | 7% |
| Unknown | 23 | 32% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 12 September 2017.
All research outputs
#22,764,772
of 25,382,440 outputs
Outputs from Breast cancer targets and therapy
#285
of 324 outputs
Outputs of similar age
#285,015
of 324,443 outputs
Outputs of similar age from Breast cancer targets and therapy
#20
of 24 outputs
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