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Negatively charged silver nanoparticles with potent antibacterial activity and reduced toxicity for pharmaceutical preparations

Overview of attention for article published in International Journal of Nanomedicine, March 2017
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About this Attention Score

  • Average Attention Score compared to outputs of the same age
  • Above-average Attention Score compared to outputs of the same age and source (64th percentile)

Mentioned by

twitter
3 tweeters

Citations

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80 Dimensions

Readers on

mendeley
128 Mendeley
Title
Negatively charged silver nanoparticles with potent antibacterial activity and reduced toxicity for pharmaceutical preparations
Published in
International Journal of Nanomedicine, March 2017
DOI 10.2147/ijn.s127799
Pubmed ID
Authors

Lucia Salvioni, Elisabetta Galbiati, Veronica Collico, Giulia Alessio, Svetlana Avvakumova, Fabio Corsi, Paolo Tortora, Davide Prosperi, Miriam Colombo

Abstract

The discovery of new solutions with antibacterial activity as efficient and safe alternatives to common preservatives (such as parabens) and to combat emerging infections and drug-resistant bacterial pathogens is highly expected in cosmetics and pharmaceutics. Colloidal silver nanoparticles (NPs) are attracting interest as novel effective antimicrobial agents for the prevention of several infectious diseases. Water-soluble, negatively charged silver nanoparticles (AgNPs) were synthesized by reduction with citric and tannic acid and characterized by transmission electron microscopy, dynamic light scattering, zeta potential, differential centrifuge sedimentation, and ultraviolet-visible spectroscopy. AgNPs were tested with model Gram-negative and Gram-positive bacteria in comparison to two different kinds of commercially available AgNPs. In this work, AgNPs with higher antibacterial activity compared to the commercially available colloidal silver solutions were prepared and investigated. Bacteria were plated and the antibacterial activity was tested at the same concentration of silver ions in all samples. The AgNPs did not show any significant reduction in the antibacterial activity for an acceptable time period. In addition, AgNPs were transferred to organic phase and retained their antibacterial efficacy in both aqueous and nonaqueous media and exhibited no toxicity in eukaryotic cells. We developed AgNPs with a 20 nm diameter and negative zeta potential with powerful antibacterial activity and low toxicity compared to currently available colloidal silver, suitable for cosmetic preservatives and pharmaceutical preparations administrable to humans and/or animals as needed.

Twitter Demographics

The data shown below were collected from the profiles of 3 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 128 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 128 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 29 23%
Student > Master 17 13%
Researcher 14 11%
Student > Bachelor 13 10%
Other 7 5%
Other 18 14%
Unknown 30 23%
Readers by discipline Count As %
Agricultural and Biological Sciences 15 12%
Chemistry 14 11%
Biochemistry, Genetics and Molecular Biology 11 9%
Engineering 10 8%
Materials Science 6 5%
Other 29 23%
Unknown 43 34%

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 05 October 2020.
All research outputs
#13,711,582
of 22,410,616 outputs
Outputs from International Journal of Nanomedicine
#1,513
of 3,742 outputs
Outputs of similar age
#149,881
of 279,760 outputs
Outputs of similar age from International Journal of Nanomedicine
#24
of 70 outputs
Altmetric has tracked 22,410,616 research outputs across all sources so far. This one is in the 37th percentile – i.e., 37% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,742 research outputs from this source. They receive a mean Attention Score of 4.3. This one has gotten more attention than average, scoring higher than 56% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 279,760 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 44th percentile – i.e., 44% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 70 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 64% of its contemporaries.