| Title |
Age and disease-related structural changes in the retinal pigment epithelium
|
|---|---|
| Published in |
Clinical Ophthalmology, June 2008
|
| DOI | 10.2147/opth.s2151 |
| Pubmed ID | |
| Authors |
Vera L Bonilha |
| Abstract |
As the retinal pigment epithelium (RPE) ages, a number of structural changes occur, including loss of melanin granules, increase in the density of residual bodies, accumulation of lipofuscin, accumulation of basal deposits on or within Bruch's membrane, formation of drusen (between the basal lamina of the RPE and the inner collagenous layer of Bruch's membrane), thickening of Bruch's membrane, microvilli atrophy and disorganization of the basal infoldings. Although these changes are well known, the basic mechanisms involved in them are frequently poorly understood. These age-related changes progress slowly and vary in severity in different individuals. These changes are also found in age-related macular degeneration (AMD), a late onset disease that severely impacts the RPE, but they are much more pronounced than during normal aging. However, the changes in AMD lead to severe loss of vision. Given the many supporting functions which the RPE serves for the retina, it is important to decipher the age-related changes in this epithelium in order to understand age-related changes in vision. |
Mendeley readers
The data shown below were compiled from readership statistics for 184 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Finland | 1 | <1% |
| United Kingdom | 1 | <1% |
| Philippines | 1 | <1% |
| Unknown | 181 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 32 | 17% |
| Researcher | 26 | 14% |
| Student > Bachelor | 24 | 13% |
| Student > Master | 23 | 13% |
| Student > Postgraduate | 12 | 7% |
| Other | 25 | 14% |
| Unknown | 42 | 23% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 34 | 18% |
| Medicine and Dentistry | 34 | 18% |
| Biochemistry, Genetics and Molecular Biology | 31 | 17% |
| Neuroscience | 13 | 7% |
| Engineering | 12 | 7% |
| Other | 16 | 9% |
| Unknown | 44 | 24% |
Attention Score in Context
This research output has an Altmetric Attention Score of 9. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 25 April 2024.
All research outputs
#3,798,611
of 25,374,647 outputs
Outputs from Clinical Ophthalmology
#353
of 3,712 outputs
Outputs of similar age
#11,858
of 97,665 outputs
Outputs of similar age from Clinical Ophthalmology
#3
of 14 outputs
Altmetric has tracked 25,374,647 research outputs across all sources so far. Compared to these this one has done well and is in the 83rd percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 3,712 research outputs from this source. They receive a mean Attention Score of 4.9. This one has done particularly well, scoring higher than 90% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 97,665 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 84% of its contemporaries.
We're also able to compare this research output to 14 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 71% of its contemporaries.