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Enhanced dermal delivery of diflucortolone valerate using lecithin/chitosan nanoparticles: in-vitro and in-vivo evaluations

Overview of attention for article published in International Journal of Nanomedicine, January 2013
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1 tweeter
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1 Facebook page

Citations

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35 Dimensions

Readers on

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47 Mendeley
Title
Enhanced dermal delivery of diflucortolone valerate using lecithin/chitosan nanoparticles: in-vitro and in-vivo evaluations
Published in
International Journal of Nanomedicine, January 2013
DOI 10.2147/ijn.s40519
Pubmed ID
Authors

Ipek Ozcan, Erkan Azizoglu, Taner Senyigit, Ozyazici, Ozgen Ozer

Abstract

The objective of this study was to prepare a suitable formulation for dermal delivery of diflucortolone valerate (DFV) that would maintain the localization in skin layers without any penetration and to optimize efficiency of DFV. Drug-loaded lecithin/chitosan nanoparticles with high entrapment efficiency (86.8%), were successfully prepared by ionic interaction technique. Sustained release of DFV was achieved without any initial burst release. Nanoparticles were also incorporated into chitosan gel at different ratios for preparing a more suitable formulation for topical drug delivery with adequate viscosity. In ex-vivo permeation studies, nanoparticles increased the accumulation of DFV especially in the stratum corneum + epidermis of rat skin without any significant permeation. Retention of DFV from nanoparticle in chitosan gel formulation (0.01%) was twofold higher than commercial cream, although it contained ten times less DFV. Nanoparticles in gel formulations produced significantly higher edema inhibition in rats compared with commercial cream in in-vivo studies. Skin blanching assay using a chromameter showed vasoconstriction similar to that of the commercial product. There were no barrier function changes upon application of nanoparticles. In-vitro and in-vivo results demonstrated that lecithin/chitosan nanoparticles in chitosan gel may be a promising carrier for dermal delivery of DFV in various skin disorders.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 47 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 47 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 11 23%
Student > Master 10 21%
Student > Bachelor 7 15%
Student > Ph. D. Student 4 9%
Other 3 6%
Other 6 13%
Unknown 6 13%
Readers by discipline Count As %
Pharmacology, Toxicology and Pharmaceutical Science 14 30%
Medicine and Dentistry 6 13%
Agricultural and Biological Sciences 5 11%
Chemistry 3 6%
Biochemistry, Genetics and Molecular Biology 2 4%
Other 9 19%
Unknown 8 17%

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 04 March 2018.
All research outputs
#7,595,848
of 12,593,681 outputs
Outputs from International Journal of Nanomedicine
#1,101
of 2,475 outputs
Outputs of similar age
#93,024
of 198,771 outputs
Outputs of similar age from International Journal of Nanomedicine
#13
of 18 outputs
Altmetric has tracked 12,593,681 research outputs across all sources so far. This one is in the 37th percentile – i.e., 37% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,475 research outputs from this source. They receive a mean Attention Score of 3.0. This one is in the 41st percentile – i.e., 41% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 198,771 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 49th percentile – i.e., 49% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 18 others from the same source and published within six weeks on either side of this one. This one is in the 27th percentile – i.e., 27% of its contemporaries scored the same or lower than it.