| Title |
Airway epithelial platelet-activating factor receptor expression is markedly upregulated in chronic obstructive pulmonary disease
|
|---|---|
| Published in |
International Journal of Chronic Obstructive Pulmonary Disease, August 2014
|
| DOI | 10.2147/copd.s67044 |
| Pubmed ID | |
| Authors |
Shakti Dhar Shukla, Sukhwinder Singh Sohal, Malik Quasir Mahmood, David Reid, Hans Konrad Muller, Eugene Haydn Walters |
| Abstract |
We recently published that platelet-activating factor receptor (PAFr) is upregulated on the epithelium of the proximal airways of current smokers and also in bronchial epithelial cells exposed to cigarette smoke extract. These treated cells also showed upregulation of Streptococcus pneumoniae adhesion. Bacterial wall phosphorylcholine specifically binds to PAFr expressed on airway epithelium, thus facilitating adherence and tissue invasion, which may be relevant to chronic obstructive pulmonary disease (COPD). Moreover, the use of inhaled corticosteroids (ICS) in COPD patients is associated with an increased risk of invasive respiratory pneumococcal infections. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 79 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 1% |
| Denmark | 1 | 1% |
| Unknown | 77 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 14 | 18% |
| Student > Master | 13 | 16% |
| Student > Ph. D. Student | 8 | 10% |
| Researcher | 6 | 8% |
| Student > Doctoral Student | 4 | 5% |
| Other | 13 | 16% |
| Unknown | 21 | 27% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 24 | 30% |
| Agricultural and Biological Sciences | 8 | 10% |
| Pharmacology, Toxicology and Pharmaceutical Science | 4 | 5% |
| Unspecified | 4 | 5% |
| Nursing and Health Professions | 3 | 4% |
| Other | 13 | 16% |
| Unknown | 23 | 29% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 22 August 2014.
All research outputs
#20,656,161
of 25,373,627 outputs
Outputs from International Journal of Chronic Obstructive Pulmonary Disease
#2,078
of 2,577 outputs
Outputs of similar age
#175,426
of 240,206 outputs
Outputs of similar age from International Journal of Chronic Obstructive Pulmonary Disease
#21
of 25 outputs
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So far Altmetric has tracked 2,577 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.5. This one is in the 6th percentile – i.e., 6% of its peers scored the same or lower than it.
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