| Title |
Enhanced brain delivery of lamotrigine with Pluronic® P123-based nanocarrier
|
|---|---|
| Published in |
International Journal of Nanomedicine, August 2014
|
| DOI | 10.2147/ijn.s62263 |
| Pubmed ID | |
| Authors |
Jian-Sheng Liu, Jian-Hong Wang, Jie Zhou, Xing-Hua Tang, Lan Xu, Teng Shen, Xun-Yi Wu, Zhen Hong |
| Abstract |
P-glycoprotein (P-gp) mediated drug efflux across the blood-brain barrier (BBB) is an important mechanism underlying poor brain penetration of certain antiepileptic drugs (AEDs). Nanomaterials, as drug carriers, can overcome P-gp activity and improve the targeted delivery of AEDs. However, their applications in the delivery of AEDs have not been adequately investigated. The objective of this study was to develop a nano-scale delivery system to improve the solubility and brain penetration of the antiepileptic drug lamotrigine (LTG). |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 72 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| India | 1 | 1% |
| Poland | 1 | 1% |
| Unknown | 70 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 14 | 19% |
| Student > Master | 9 | 13% |
| Student > Doctoral Student | 7 | 10% |
| Researcher | 5 | 7% |
| Student > Bachelor | 5 | 7% |
| Other | 9 | 13% |
| Unknown | 23 | 32% |
| Readers by discipline | Count | As % |
|---|---|---|
| Pharmacology, Toxicology and Pharmaceutical Science | 10 | 14% |
| Agricultural and Biological Sciences | 7 | 10% |
| Chemistry | 7 | 10% |
| Medicine and Dentistry | 5 | 7% |
| Biochemistry, Genetics and Molecular Biology | 3 | 4% |
| Other | 13 | 18% |
| Unknown | 27 | 38% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 26 August 2014.
All research outputs
#22,758,309
of 25,373,627 outputs
Outputs from International Journal of Nanomedicine
#3,598
of 4,123 outputs
Outputs of similar age
#206,168
of 240,206 outputs
Outputs of similar age from International Journal of Nanomedicine
#55
of 62 outputs
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We're also able to compare this research output to 62 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.