| Title |
Atypical depression: current perspectives
|
|---|---|
| Published in |
Neuropsychiatric Disease and Treatment, September 2017
|
| DOI | 10.2147/ndt.s147317 |
| Pubmed ID | |
| Authors |
Dorota Łojko, Janusz K Rybakowski |
| Abstract |
The history and present status of the definition, prevalence, neurobiology, and treatment of atypical depression (AD) is presented. The concept of AD has evolved through the years, and currently, in Diagnostic and Statistical Manual of Mental Disorders (DSM), Fifth Edition, the specifier of depressive episode with atypical feature is present for both diagnostic groups, that is, depressive disorders and bipolar and related disorders. This specifier includes mood reactivity, hyperphagia, hypersomnia, leaden paralysis, and interpersonal rejection sensitivity. Prevalence rates of AD are variable, depending on the criteria, methodology, and settings. The results of epidemiological studies using DSM criteria suggest that 15%-29% of depressed patients have AD, and the results of clinical studies point to a prevalence of 18%-36%. A relationship of AD with bipolar depression, seasonal depression, and obesity has also been postulated. Pathogenic research has been mostly focused on distinguishing AD from melancholic depression. The differences have been found in biochemical studies in the areas of hypothalamic-pituitary-adrenal axis, inflammatory markers, and the leptin system, although the results obtained are frequently controversial. A number of findings concerning such differences have also been obtained using neuroimaging and neurophysiological and neuropsychological methods. An initial concept of AD as a preferentially monoamine oxidase inhibitor-responsive depression, although confirmed in some further studies, is of limited use nowadays. Currently, despite numerous drug trials, there are no comprehensive treatment guidelines for AD. We finalize the article by describing the future research perspectives for the definition, neurobiology, and treatment. A better specification of diagnostic criteria and description of clinical picture, a genome-wide association study of AD, and establishing updated treatment recommendations for this clinical phenomenon should be the priorities for the coming years. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 2 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Practitioners (doctors, other healthcare professionals) | 1 | 50% |
| Members of the public | 1 | 50% |
Mendeley readers
The data shown below were compiled from readership statistics for 215 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 215 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 33 | 15% |
| Student > Bachelor | 24 | 11% |
| Researcher | 21 | 10% |
| Student > Ph. D. Student | 20 | 9% |
| Other | 17 | 8% |
| Other | 37 | 17% |
| Unknown | 63 | 29% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 48 | 22% |
| Psychology | 26 | 12% |
| Neuroscience | 21 | 10% |
| Biochemistry, Genetics and Molecular Biology | 12 | 6% |
| Nursing and Health Professions | 9 | 4% |
| Other | 31 | 14% |
| Unknown | 68 | 32% |
Attention Score in Context
This research output has an Altmetric Attention Score of 46. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 25 March 2024.
All research outputs
#912,166
of 25,382,440 outputs
Outputs from Neuropsychiatric Disease and Treatment
#118
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#18,610
of 324,453 outputs
Outputs of similar age from Neuropsychiatric Disease and Treatment
#3
of 77 outputs
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