| Title |
Selective estrogen receptor modulators: tissue specificity and clinical utility
|
|---|---|
| Published in |
Clinical Interventions in Aging, August 2014
|
| DOI | 10.2147/cia.s66690 |
| Pubmed ID | |
| Authors |
Stephen Martinkovich, Darshan Shah, Sonia Lobo Planey, John A Arnott |
| Abstract |
Selective estrogen receptor modulators (SERMs) are a diverse group of nonsteroidal compounds that function as agonists or antagonists for estrogen receptors (ERs) in a target gene-specific and tissue-specific fashion. SERM specificity involves tissue-specific expression of ER subtypes, differential expression of co-regulatory proteins in various tissues, and varying ER conformational changes induced by ligand binding. To date, the major clinical applications of SERMs are their use in the prevention and treatment of breast cancer, the prevention of osteoporosis, and the maintenance of beneficial serum lipid profiles in postmenopausal women. However, SERMs have also been found to promote adverse effects, including thromboembolic events and, in some cases, carcinogenesis, that have proven to be obstacles in their clinical utility. In this review, we discuss the mechanisms of SERM tissue specificity and highlight the therapeutic application of well-known and emergent SERMs. |
Mendeley readers
The data shown below were compiled from readership statistics for 214 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 214 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 36 | 17% |
| Student > Bachelor | 36 | 17% |
| Student > Master | 30 | 14% |
| Researcher | 19 | 9% |
| Student > Doctoral Student | 14 | 7% |
| Other | 34 | 16% |
| Unknown | 45 | 21% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 41 | 19% |
| Medicine and Dentistry | 29 | 14% |
| Agricultural and Biological Sciences | 28 | 13% |
| Pharmacology, Toxicology and Pharmaceutical Science | 26 | 12% |
| Chemistry | 12 | 6% |
| Other | 24 | 11% |
| Unknown | 54 | 25% |
Attention Score in Context
This research output has an Altmetric Attention Score of 9. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 April 2024.
All research outputs
#3,798,287
of 25,373,627 outputs
Outputs from Clinical Interventions in Aging
#426
of 1,968 outputs
Outputs of similar age
#36,269
of 240,208 outputs
Outputs of similar age from Clinical Interventions in Aging
#9
of 46 outputs
Altmetric has tracked 25,373,627 research outputs across all sources so far. Compared to these this one has done well and is in the 83rd percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,968 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 11.1. This one has done well, scoring higher than 78% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 240,208 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 84% of its contemporaries.
We're also able to compare this research output to 46 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 80% of its contemporaries.