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A bone-resorption surface-targeting nanoparticle to deliver anti-miR214 for osteoporosis therapy

Overview of attention for article published in International Journal of Nanomedicine, October 2017
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About this Attention Score

  • Average Attention Score compared to outputs of the same age
  • Above-average Attention Score compared to outputs of the same age and source (51st percentile)

Mentioned by

twitter
3 tweeters

Citations

dimensions_citation
42 Dimensions

Readers on

mendeley
53 Mendeley
Title
A bone-resorption surface-targeting nanoparticle to deliver anti-miR214 for osteoporosis therapy
Published in
International Journal of Nanomedicine, October 2017
DOI 10.2147/ijn.s139775
Pubmed ID
Authors

Mingxiang Cai, Li Yang, Shufan Zhang, Jiafan Liu, Yao Sun, Xiaogang Wang

Abstract

With increasing fracture risks due to fragility, osteoporosis is a global health problem threatening postmenopausal women. In these patients, osteoclasts play leading roles in bone loss and fracture. How to inhibit osteoclast activity is the key issue for osteoporosis treatment. In recent years, miRNA-based gene therapy through gene regulation has been considered a potential therapeutic method. However, in light of the side effects, the use of therapeutic miRNAs in osteoporosis treatment is still limited by the lack of tissue/cell-specific delivery systems. Here, we developed polyurethane (PU) nanomicelles modified by the acidic peptide Asp(8). Our data showed that without overt toxicity or eliciting an immune response, this delivery system encapsulated and selectively deliver miRNAs to OSCAR(+) osteoclasts at bone-resorption surface in vivo. With the Asp(8)-PU delivery system, anti-miR214 was delivered to osteoclasts, and bone microarchitecture and bone mass were improved in ovariectomized osteoporosis mice. Therefore, Asp(8)-PU could be a useful bone-resorption surface-targeting delivery system for treatment of osteoclast-induced bone diseases and aging-related osteoporosis.

Twitter Demographics

The data shown below were collected from the profiles of 3 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 53 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 53 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 10 19%
Student > Master 9 17%
Student > Postgraduate 6 11%
Researcher 4 8%
Student > Bachelor 3 6%
Other 5 9%
Unknown 16 30%
Readers by discipline Count As %
Medicine and Dentistry 9 17%
Biochemistry, Genetics and Molecular Biology 7 13%
Chemistry 4 8%
Engineering 4 8%
Agricultural and Biological Sciences 3 6%
Other 9 17%
Unknown 17 32%

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 10 November 2017.
All research outputs
#7,276,965
of 12,122,714 outputs
Outputs from International Journal of Nanomedicine
#1,053
of 2,388 outputs
Outputs of similar age
#143,162
of 274,799 outputs
Outputs of similar age from International Journal of Nanomedicine
#28
of 64 outputs
Altmetric has tracked 12,122,714 research outputs across all sources so far. This one is in the 37th percentile – i.e., 37% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,388 research outputs from this source. They receive a mean Attention Score of 3.0. This one is in the 41st percentile – i.e., 41% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 274,799 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 43rd percentile – i.e., 43% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 64 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 51% of its contemporaries.