| Title |
Propofol prevents electroconvulsive-shock-induced memory impairment through regulation of hippocampal synaptic plasticity in a rat model of depression
|
|---|---|
| Published in |
Neuropsychiatric Disease and Treatment, September 2014
|
| DOI | 10.2147/ndt.s67108 |
| Pubmed ID | |
| Authors |
Jie Luo, Su Min, Ke Wei, Jun Cao, Bin Wang, Ping Li, Jun Dong, Yuanyuan Liu |
| Abstract |
Although a rapid and efficient psychiatric treatment, electroconvulsive therapy (ECT) induces memory impairment. Modified ECT requires anesthesia for safety purposes. Although traditionally found to exert amnesic effects in general anesthesia, which is an inherent part of modified ECT, some anesthetics have been found to protect against ECT-induced cognitive impairment. However, the mechanisms remain unclear. We investigated the effects of propofol (2,6-diisopropylphenol) on memory in depressed rats undergoing electroconvulsive shock (ECS), the analog of ECT in animals, under anesthesia as well as its mechanisms. |
Mendeley readers
The data shown below were compiled from readership statistics for 41 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 41 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 10 | 24% |
| Student > Master | 6 | 15% |
| Student > Bachelor | 4 | 10% |
| Researcher | 4 | 10% |
| Student > Postgraduate | 3 | 7% |
| Other | 5 | 12% |
| Unknown | 9 | 22% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 10 | 24% |
| Medicine and Dentistry | 6 | 15% |
| Agricultural and Biological Sciences | 5 | 12% |
| Psychology | 4 | 10% |
| Pharmacology, Toxicology and Pharmaceutical Science | 2 | 5% |
| Other | 4 | 10% |
| Unknown | 10 | 24% |