| Title |
Diversity and evolution of drug resistance mechanisms in Mycobacterium tuberculosis
|
|---|---|
| Published in |
Infection and Drug Resistance, October 2017
|
| DOI | 10.2147/idr.s144446 |
| Pubmed ID | |
| Authors |
Mashael Al-Saeedi, Sahal Al-Hajoj |
| Abstract |
Despite the efficacy of antibiotics to protect humankind against many deadly pathogens, such as Mycobacterium tuberculosis, nothing can prevent the emergence of drug-resistant strains. Several mechanisms facilitate drug resistance in M. tuberculosis including compensatory evolution, epistasis, clonal interference, cell wall integrity, efflux pumps, and target mimicry. In this study, we present recent findings relevant to these mechanisms, which can enable the discovery of new drug targets and subsequent development of novel drugs for treatment of drug-resistant M. tuberculosis. |
X Demographics
The data shown below were collected from the profiles of 5 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 20% |
| Saudi Arabia | 1 | 20% |
| Unknown | 3 | 60% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 5 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 194 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 194 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 31 | 16% |
| Student > Master | 27 | 14% |
| Student > Ph. D. Student | 22 | 11% |
| Other | 14 | 7% |
| Researcher | 11 | 6% |
| Other | 26 | 13% |
| Unknown | 63 | 32% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 42 | 22% |
| Immunology and Microbiology | 23 | 12% |
| Medicine and Dentistry | 20 | 10% |
| Agricultural and Biological Sciences | 14 | 7% |
| Pharmacology, Toxicology and Pharmaceutical Science | 10 | 5% |
| Other | 20 | 10% |
| Unknown | 65 | 34% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 05 February 2019.
All research outputs
#13,219,568
of 23,005,189 outputs
Outputs from Infection and Drug Resistance
#376
of 1,681 outputs
Outputs of similar age
#155,340
of 322,475 outputs
Outputs of similar age from Infection and Drug Resistance
#8
of 14 outputs
Altmetric has tracked 23,005,189 research outputs across all sources so far. This one is in the 42nd percentile – i.e., 42% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,681 research outputs from this source. They receive a mean Attention Score of 3.8. This one has done well, scoring higher than 76% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 322,475 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 51% of its contemporaries.
We're also able to compare this research output to 14 others from the same source and published within six weeks on either side of this one. This one is in the 42nd percentile – i.e., 42% of its contemporaries scored the same or lower than it.