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Managing resistant hypertension: focus on mineralocorticoid-receptor antagonists

Overview of attention for article published in Vascular Health and Risk Management, October 2017
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Mentioned by

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2 tweeters

Citations

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14 Dimensions

Readers on

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44 Mendeley
Title
Managing resistant hypertension: focus on mineralocorticoid-receptor antagonists
Published in
Vascular Health and Risk Management, October 2017
DOI 10.2147/vhrm.s138599
Pubmed ID
Authors

Juan Carlos Yugar-Toledo, Rodrigo Modolo, Ana Paula de Faria, Heitor Moreno

Abstract

Mineralocorticoid-receptor antagonists (MRAs) have proven to be effective in some types of hypertension, especially in resistant hypertension (RHTN). In this phenotype of hypertension, the renin-angiotensin-aldosterone pathway plays an important role, with MRAs being especially effective in reducing blood pressure. In this review, we show the relevance of aldosterone in RHTN, as well as some clinical characteristics of this condition and the main concepts involving its pathophysiology and cardiovascular damage. We analyzed the mechanisms of action and clinical effects of two current MRAs - spironolactone and eplerenone - both of which are useful in RHTN, with special attention to the former. RHTN represents a significant minority (10%-15%) of hypertension cases. However, primary-care physicians, cardiologists, nephrologists, neurologists, and geriatricians face this health problem on a daily basis. MRAs are likely one of the best pharmacological options in RHTN patients; however, they are still underused.

Twitter Demographics

The data shown below were collected from the profiles of 2 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 44 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 44 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 10 23%
Student > Bachelor 7 16%
Other 3 7%
Student > Ph. D. Student 3 7%
Student > Doctoral Student 2 5%
Other 9 20%
Unknown 10 23%
Readers by discipline Count As %
Medicine and Dentistry 20 45%
Biochemistry, Genetics and Molecular Biology 4 9%
Computer Science 2 5%
Agricultural and Biological Sciences 1 2%
Pharmacology, Toxicology and Pharmaceutical Science 1 2%
Other 4 9%
Unknown 12 27%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 October 2017.
All research outputs
#7,514,935
of 12,016,495 outputs
Outputs from Vascular Health and Risk Management
#336
of 518 outputs
Outputs of similar age
#160,295
of 284,211 outputs
Outputs of similar age from Vascular Health and Risk Management
#4
of 7 outputs
Altmetric has tracked 12,016,495 research outputs across all sources so far. This one is in the 23rd percentile – i.e., 23% of other outputs scored the same or lower than it.
So far Altmetric has tracked 518 research outputs from this source. They receive a mean Attention Score of 3.7. This one is in the 19th percentile – i.e., 19% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 284,211 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 33rd percentile – i.e., 33% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 7 others from the same source and published within six weeks on either side of this one. This one has scored higher than 3 of them.