| Title |
Hematopoietic stem cell transplantation in a severe refractory Crohn’s disease patient with intestinal stoma: a case report
|
|---|---|
| Published in |
International Medical Case Reports Journal, October 2017
|
| DOI | 10.2147/imcrj.s139552 |
| Pubmed ID | |
| Authors |
Milton Artur Ruiz, Roberto Luiz Kaiser, Luiz Gustavo de Quadros, Gustavo Henrique Xavier Caseiro, Aderson Francisco Oliveira, Tatiana Peña-Arciniegas, Lilian Piron-Ruiz, Fernanda Soubhia Liedtke Kaiser, Vera Lucia Oliveira |
| Abstract |
Hematopoietic stem cell transplantation (HSCT) can be used in the treatment of patients with refractory Crohn's disease (CD) when no alternative treatment is available. However, HSCT increases the risk of infections, in particular during the aplasia of mobilization and conditioning. Moreover, intestinal stomas in CD augment the risk of morbidity in immunocompromised patients and under aplastic conditions. The objective of this report was to describe the results of the first year after HSCT in a CD patient with an intestinal stoma. The patient was assessed in respect to disease symptoms and endoscopic findings before the procedure and 30, 90, 180, and 365 days after HSCT. No complications were observed during mobilization and conditioning with sufficient CD34(+) cells being harvested in just one apheresis session. Toxicity was restricted to the hematological series. Scores of all the CD indexes and the quality of life of the patient improved. However, two of three endoscopic scores remained unchanged even though improvements were found in the appearance of the lesions. HSCT may be an alternative treatment for refractory CD in patients with an intestinal stoma, and a priori, carefully selected patients with stomas should not be excluded as candidates for this procedure. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 2 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 27 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 27 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 5 | 19% |
| Student > Master | 3 | 11% |
| Student > Ph. D. Student | 3 | 11% |
| Student > Doctoral Student | 2 | 7% |
| Other | 2 | 7% |
| Other | 6 | 22% |
| Unknown | 6 | 22% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 13 | 48% |
| Biochemistry, Genetics and Molecular Biology | 2 | 7% |
| Economics, Econometrics and Finance | 1 | 4% |
| Pharmacology, Toxicology and Pharmaceutical Science | 1 | 4% |
| Psychology | 1 | 4% |
| Other | 1 | 4% |
| Unknown | 8 | 30% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 25 October 2017.
All research outputs
#15,481,888
of 23,006,268 outputs
Outputs from International Medical Case Reports Journal
#168
of 375 outputs
Outputs of similar age
#201,844
of 322,475 outputs
Outputs of similar age from International Medical Case Reports Journal
#3
of 6 outputs
Altmetric has tracked 23,006,268 research outputs across all sources so far. This one is in the 22nd percentile – i.e., 22% of other outputs scored the same or lower than it.
So far Altmetric has tracked 375 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 9.5. This one is in the 38th percentile – i.e., 38% of its peers scored the same or lower than it.
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