| Title |
Association of TNF-alpha G-308A gene polymorphism with depression: a meta-analysis
|
|---|---|
| Published in |
Neuropsychiatric Disease and Treatment, October 2017
|
| DOI | 10.2147/ndt.s143434 |
| Pubmed ID | |
| Authors |
Kwang-Hee Shin, Hyeon Cheol Jeong, Dong-Hee Choi, Sung Nyun Kim, Tae-Eun Kim |
| Abstract |
Although many studies have investigated the association of a single nucleotide polymorphism in TNF-α G-308A gene with depression, their association is still controversial. To clarify this, we performed a meta-analysis. Studies related to TNF-α G-308A and depression were retrieved from PubMed, Medline, Embase, and Scopus (up to April 18, 2017). The odds ratios (ORs) and 95% confidence intervals (CIs) were estimated in the models of allele comparison (G vs A), homozygote comparison (GG vs AA), dominant (GG vs GA + AA), and recessive (GG + GA vs AA) to estimate the strength of the associations. A total of 10 case-control studies were included in this meta-analysis. Overall, no significant association between TNF-α G-308A and depression was found (G vs A: OR [95% CI] =1.09 [0.92, 1.29]; GG vs AA: 1.24 [0.71, 2.15]; GG vs GA + AA: 1.01 [0.76, 1.35]; GG + GA vs AA: 1.22 [0.70, 2.13]). In subgroup analyses by ethnicity or age group, no statistically significant association between TNF-α G-308A polymorphisms and depression was shown. This meta-analysis revealed that TNF-α G-308A polymorphism is not associated with susceptibility to depression. |
Mendeley readers
The data shown below were compiled from readership statistics for 26 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 26 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 7 | 27% |
| Other | 3 | 12% |
| Student > Master | 3 | 12% |
| Lecturer | 2 | 8% |
| Student > Doctoral Student | 2 | 8% |
| Other | 6 | 23% |
| Unknown | 3 | 12% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 5 | 19% |
| Biochemistry, Genetics and Molecular Biology | 3 | 12% |
| Medicine and Dentistry | 3 | 12% |
| Agricultural and Biological Sciences | 2 | 8% |
| Psychology | 2 | 8% |
| Other | 6 | 23% |
| Unknown | 5 | 19% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 26 October 2017.
All research outputs
#22,764,772
of 25,382,440 outputs
Outputs from Neuropsychiatric Disease and Treatment
#2,583
of 3,131 outputs
Outputs of similar age
#291,092
of 331,218 outputs
Outputs of similar age from Neuropsychiatric Disease and Treatment
#50
of 64 outputs
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