Title |
Transient global amnesia: current perspectives
|
---|---|
Published in |
Neuropsychiatric Disease and Treatment, October 2017
|
DOI | 10.2147/ndt.s130710 |
Pubmed ID | |
Authors |
David R Spiegel, Justin Smith, Ryan R Wade, Nithya Cherukuru, Aneel Ursani, Yuliya Dobruskina, Taylor Crist, Robert F Busch, Rahim M Dhanani, Nicholas Dreyer |
Abstract |
Transient global amnesia (TGA) is a clinical syndrome characterized by the sudden onset of an extraordinarily large reduction of anterograde and a somewhat milder reduction of retrograde episodic long-term memory. Additionally, executive functions are described as diminished. Although it is suggested that various factors, such as migraine, focal ischemia, venous flow abnormalities, and epileptic phenomena, are involved in the pathophysiology and differential diagnosis of TGA, the factors triggering the emergence of these lesions are still elusive. Recent data suggest that the vulnerability of CA1 neurons to metabolic stress plays a pivotal part in the pathophysiological cascade, leading to an impairment of hippocampal function during TGA. In this review, we discuss clinical aspects, new imaging findings, and recent clinical-epidemiological data with regard to the phenotype, functional anatomy, and putative cellular mechanisms of TGA. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Spain | 2 | 40% |
France | 1 | 20% |
Unknown | 2 | 40% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Practitioners (doctors, other healthcare professionals) | 2 | 40% |
Members of the public | 2 | 40% |
Scientists | 1 | 20% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 157 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Bachelor | 28 | 18% |
Other | 13 | 8% |
Student > Ph. D. Student | 11 | 7% |
Researcher | 11 | 7% |
Student > Master | 10 | 6% |
Other | 31 | 20% |
Unknown | 53 | 34% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 43 | 27% |
Neuroscience | 17 | 11% |
Psychology | 16 | 10% |
Engineering | 4 | 3% |
Agricultural and Biological Sciences | 2 | 1% |
Other | 14 | 9% |
Unknown | 61 | 39% |