Title |
Human mesenchymal stem cell-derived iron oxide exosomes allow targeted ablation of tumor cells via magnetic hyperthermia
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Published in |
International Journal of Nanomedicine, October 2017
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DOI | 10.2147/ijn.s145096 |
Pubmed ID | |
Authors |
U Altanerova, M Babincova, P Babinec, K Benejova, J Jakubechova, V Altanerova, M Zduriencikova, V Repiska, C Altaner |
Abstract |
Magnetic hyperthermia, or the heating of tissues using magnetic materials, is a promising approach for treating cancer. We found that human mesenchymal stem cells (MSCs) isolated from various tissues and MSCs expressing the yeast cytosine deaminase∷uracil phosphoribosyl transferase suicide fusion gene (yCD∷UPRT) can be labeled with Venofer, an iron oxide carbohydrate nanoparticle. Venofer labeling did not affect cell proliferation or the ability to home to tumors. All Venofer-labeled MSCs released exosomes that contained iron oxide. Furthermore, these exosomes were efficiently endocytosed by tumor cells. Exosomes from Venofer-labeled MSCs expressing the yCD∷UPRT gene in the presence of the prodrug 5-fluorocytosine inhibited tumor growth in a dose-dependent fashion. The treated tumor cells were also effectively ablated following induction of hyperthermia using an external alternating magnetic field. Cumulatively, we found that magnetic nanoparticles packaged into MSC exosomes are efficiently endocytosed by tumor cells, facilitating targeted tumor cell ablation via magnetically induced hyperthermia. |
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Unknown | 1 | 100% |
Demographic breakdown
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 95 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 18 | 19% |
Student > Bachelor | 14 | 15% |
Student > Master | 12 | 13% |
Researcher | 9 | 9% |
Student > Doctoral Student | 6 | 6% |
Other | 14 | 15% |
Unknown | 22 | 23% |
Readers by discipline | Count | As % |
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Biochemistry, Genetics and Molecular Biology | 16 | 17% |
Medicine and Dentistry | 13 | 14% |
Agricultural and Biological Sciences | 10 | 11% |
Engineering | 6 | 6% |
Pharmacology, Toxicology and Pharmaceutical Science | 6 | 6% |
Other | 18 | 19% |
Unknown | 26 | 27% |