Title |
Severe eosinophilic asthma: from the pathogenic role of interleukin-5 to the therapeutic action of mepolizumab
|
---|---|
Published in |
Drug Design, Development and Therapy, October 2017
|
DOI | 10.2147/dddt.s150656 |
Pubmed ID | |
Authors |
Corrado Pelaia, Alessandro Vatrella, Maria Teresa Busceti, Luca Gallelli, Rosa Terracciano, Rocco Savino, Girolamo Pelaia |
Abstract |
Mepolizumab is an anti-interleukin-5 (IL-5) humanized monoclonal antibody that has been recently approved as an add-on biological treatment for severe eosinophilic asthma, by both the US Food and Drug Administration (FDA) and the European Medicines Agency (EMA). Moreover, mepolizumab is also currently included within the step 5 of the Global Initiative for Asthma guidelines, as an add-on therapy for severe uncontrolled asthma. The relevant therapeutic benefits detectable in patients with refractory eosinophilic asthma receiving mepolizumab depend on the pivotal pathogenic role played by IL-5 in these subjects. Indeed, IL-5 is the key cytokine responsible for maturation, activation, proliferation, and survival of eosinophils. Therefore, IL-5 represents a strategic molecular target for anti-eosinophilic treatments. By selectively inhibiting the biological actions of IL-5, mepolizumab provides a valuable therapeutic option for patients with severe eosinophilic asthma, refractory to standard treatments including inhaled and even systemic corticosteroids. In particular, the very important advantages linked to the use of mepolizumab in these difficult-to-treat asthmatic individuals have been well documented by several different trials performed worldwide. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Canada | 1 | 14% |
Germany | 1 | 14% |
Colombia | 1 | 14% |
United States | 1 | 14% |
Unknown | 3 | 43% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 6 | 86% |
Practitioners (doctors, other healthcare professionals) | 1 | 14% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 98 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 12 | 12% |
Student > Bachelor | 12 | 12% |
Student > Postgraduate | 10 | 10% |
Student > Doctoral Student | 10 | 10% |
Student > Ph. D. Student | 9 | 9% |
Other | 18 | 18% |
Unknown | 27 | 28% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 23 | 23% |
Biochemistry, Genetics and Molecular Biology | 11 | 11% |
Pharmacology, Toxicology and Pharmaceutical Science | 9 | 9% |
Agricultural and Biological Sciences | 5 | 5% |
Immunology and Microbiology | 5 | 5% |
Other | 11 | 11% |
Unknown | 34 | 35% |